Picture seems complicated Our study, performed in C. elegans and human primary fibroblasts shows that there is an age-related decrease in metformin tolerance,

Picture seems complicated Our study, performed in C. elegans and human primary fibroblasts shows that there is an age-related decrease in metformin tolerance, which in later life leads to toxicity of all metformin doses tested. This shows possible safety risks of late life administration of metformin to individuals without diabetes," https://medicalxpress.com/news/2020-11-age-decisive-positive-negative-effects.html https://medicalxpress.com/news/2020-11-age-decisive-positive...