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Yes, there's evidence for that. However the jury is still out on whether metformin is a net benefit for people with healthy insulin sensitivity. It appears ther
by nate_meurer 5y ago
Yes, there's evidence for that. However the jury is still out on whether metformin is a net benefit for people with healthy insulin sensitivity. It appears there are negative effects:
Derek Lowe talks about the negative effects of metformin on healthy people:
https://blogs.sciencemag.org/pipeline/archives/2019/06/24/me https://blogs.sciencemag.org/pipeline/archives/2019/06/24/me...
Peter Attia talks about the same, and some interesting other considerations:
https://peterattiamd.com/191013/ https://peterattiamd.com/191013/
- dcolkitt 5y agoMetformin likely blunts the impact of high intensity exercise. But for the 65% of people living sedentary or low activity lives, it’s a straight win. Even for those who are consistent with physical fitness, the downsides can likely be avoided by waiting a few hours after the morning exercise session to dose.
- electriclove 5y agoRight, and wouldn't the non extended release version work well if taken at night and exercise in morning (or vice versa).
- birriel 5y agoFolks that take metformin for anti-aging usually take it on exercise off-days. There was concern about lactic acidosis, but it's beginning to become clear that it mostly arises in patients with comorbidities.