> Except it's a localized, self-limited amount, as mRNA cannot replicate. Well, hence my question about cytokine storm, since by definition that's an out of co

> Except it's a localized, self-limited amount, as mRNA cannot replicate. Well, hence my question about cytokine storm, since by definition that's an out of control feedback loop prompted by other cytokines and not the underlying virus any more. My question was about whether it's possible that just the spike protein could conceivably have induced that effect. Good point about the localization of it. Though, I do feel like I read somewhere you see the Spike proteins mostly around the shoulder and in the liver, so it does travel through the blood somewhat. Also, I was under the misunderstanding that cytokines were part of the adaptive immune system, and hence produced – I think? – in the bone marrow. If that were true, it wouldn't matter so much where the antigens were, since the B/T-Cells (getting confused on which is which) are produced elsewhere and have to make their way there anyway. And if that's the case, they'd be visiting the lungs. And, being adaptive, I thought it was something about the shape of covid and hence the antibodies that kicked off the storm in the lungs, and not necessarily the quantity or prevalence of the antigen in the lungs. But, turns out it's part of the innate immune system, and seems like cytokines are mostly produced near the infection itself.