The million dollar question! No one really knows. There are some theories. One thing is linoleic acid converts into endocannabinoids, which stimulate appetite

The million dollar question! No one really knows. There are some theories. One thing is linoleic acid converts into endocannabinoids, which stimulate appetite. Too much n6, too much appetite, obesity, is the theory. If you google around on e.g. pubmeb you can find various papers proposing this. But there's probably more to it than that; there are pig and mouse studies where the animals are fed isocaloric diets, but the animals eating high LA get fat. So that strongly suggests that it's not just a appetite-based overeating thing. The blog hyperlipid proposed a theory involving ROS signaling at a cellular level; my knowledge of biology and metabolism is sadly minimal, but at a very high level I think the theory is something like, "having too much linoleic acid in the diet signals cells to remain unnaturally insulin-sensitive and accumulate fat". See also: the blog Fire in a Bottle, which tries to summarize the hyperlipid theory at a less low-level, technical level. https://pubmed.ncbi.nlm.nih.gov/27350414/ https://pubmed.ncbi.nlm.nih.gov/27350414/ https://high-fat-nutrition.blogspot.com/2013/08/protons-so-far-some-sort-of-summary.html https://high-fat-nutrition.blogspot.com/2013/08/protons-so-f... https://fireinabottle.net/the-ros-theory-of-obesity/ https://fireinabottle.net/the-ros-theory-of-obesity/