3 ms·

There are a lot of studies of varying quality, some of which show benefit for IVM and HCQ. One place to find some of these compiled is https://hcqmeta.com http

There are a lot of studies of varying quality, some of which show benefit for IVM and HCQ. One place to find some of these compiled is https://hcqmeta.com https://hcqmeta.com. Beware that they don't say what their study inclusion criteria is, so one has to be more skeptical of studies that have a small N and/or high P value. The RECOVERY results for HCQ were definitely negative. Personally I'm neutral on its effectiveness, but HCQ proponents would probably say that HCQ's postulated antiviral mechanism is not effective on already hospitalized patients, since most of them would have already cleared the virus by the time they showed up to the hospital.

carbocation 5y ago
It's interesting to look at the forest plots on that page and only focus on RCTs, which are labeled. I cannot understand why someone would try to meta-analyze RCTs with observational studies when dozens of each exist. But this really hammers home (despite their misleading summary statistics at the top) that the evidence does not support an effect of HCQ on COVID-19.