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I didn't even think of this before but now that i read this, i'm curious too. So basically Linus say mRNA vaccine does not change your genetic but then he proce

by nsonha 5y ago

I didn't even think of this before but now that i read this, i'm curious too. So basically Linus say mRNA vaccine does not change your genetic but then he proceed to say that it does exactly that to fight foreign proteins and it's ok because your cell's mRNA do that anyway. Do you see the difference? I guess there is a reason to raise concerns about the novelty of the technique, if this is indeed the first time artificial mRNA is used on the general public.

kaba0 5y ago
> but then he proceed to say that it does exactly that to fight foreign proteins No he doesn’t say that and is not true. mRNAs are “commands”. They encode proteins — each triplet (of nucleotides) on it will translate to one protein building block. They are semi-stable and are actively destroyed in the cell so they can only produce a few protein molecules. So injecting mRNA will give a temporary command to the cells to produce this protein so that the body can learn to defend agains them once they are released from cells.
- nsonha 5y ago
  This is what he said and he could be wrong but I'm not making up anything > that the mRNA vaccines do is to add a dose their own specialized sequence that then makes your normal cell machinery generate that spike protein so that your body learns how to recognize it... your body now knows how to recognize and fight off a new foreign protein So what happens if some faulty proteins are created from this process, any chance they then be used to build new cells and cause disorders? I'm not on the "change genetic" argument anymore as I'm not sure what even defines that, just trying to understand the risks here.
  - kaba0 5y ago
    What Linus writes is accurate, you may have misunderstood him. A dose of mRNA is transported to a few cells, and these cells temporarily gets the command to create spike proteins. These proteins will be transported outside your body and be recognized by the immune system. There is no need to constantly create them as the immune system can learn from this alone. And it is temporary because mRNA is constantly degrading — it is a must otherwise a cell would have no way to stop manufacturing a protein after giving out a command.
    - nsonha 5y ago
      https://www.youtube.com/watch?v=oMXGGmBfkf8&t=125s https://www.youtube.com/watch?v=oMXGGmBfkf8&t=125s It says "low risk" of being integrated into the genome. Sounds like there is still a risk.
      - kaba0 5y ago
        It's not low, it's basically non-existent. It's perhaps just a needlessly defensive way of saying so in the video, since there are biologically a way for mRNA to turn into DNA. But it has an effect only on an evolutionary timescale. But my second paragraph here is about what would this cause theoretically: https://news.ycombinator.com/item?id=27468123 https://news.ycombinator.com/item?id=27468123

by nsonha 5y ago

kaba0 5y ago

> but then he proceed to say that it does exactly that to fight foreign proteins No he doesn’t say that and is not true. mRNAs are “commands”. They encode proteins — each triplet (of nucleotides) on it will translate to one protein building block. They are semi-stable and are actively destroyed in the cell so they can only produce a few protein molecules. So injecting mRNA will give a temporary command to the cells to produce this protein so that the body can learn to defend agains them once they are released from cells.

nsonha 5y ago
This is what he said and he could be wrong but I'm not making up anything > that the mRNA vaccines do is to add a dose their own specialized sequence that then makes your normal cell machinery generate that spike protein so that your body learns how to recognize it... your body now knows how to recognize and fight off a new foreign protein So what happens if some faulty proteins are created from this process, any chance they then be used to build new cells and cause disorders? I'm not on the "change genetic" argument anymore as I'm not sure what even defines that, just trying to understand the risks here.
- kaba0 5y ago
  What Linus writes is accurate, you may have misunderstood him. A dose of mRNA is transported to a few cells, and these cells temporarily gets the command to create spike proteins. These proteins will be transported outside your body and be recognized by the immune system. There is no need to constantly create them as the immune system can learn from this alone. And it is temporary because mRNA is constantly degrading — it is a must otherwise a cell would have no way to stop manufacturing a protein after giving out a command.
  - nsonha 5y ago
    https://www.youtube.com/watch?v=oMXGGmBfkf8&t=125s https://www.youtube.com/watch?v=oMXGGmBfkf8&t=125s It says "low risk" of being integrated into the genome. Sounds like there is still a risk.
    - kaba0 5y ago
      It's not low, it's basically non-existent. It's perhaps just a needlessly defensive way of saying so in the video, since there are biologically a way for mRNA to turn into DNA. But it has an effect only on an evolutionary timescale. But my second paragraph here is about what would this cause theoretically: https://news.ycombinator.com/item?id=27468123 https://news.ycombinator.com/item?id=27468123