3 ms·

> The half-life of mRNA is a few hours. Any injected mRNA will be all gone from your body in a day or two. Can someone with more knowledge comment on whether t

> The half-life of mRNA is a few hours. Any injected mRNA will be all gone from your body in a day or two. Can someone with more knowledge comment on whether this is true for components of the vaccine that aren't just the mRNA bits? I am not sure, but I assume there are various other components that form the delivery vehicle for the vaccine, stabilize it for storage, and so on. What are the actual mechanisms for those to be 'gone from the body'?

lamontcg 5y ago
The lipid nanoparticle is just lipids. Unless you happen to have an allergic reaction to the specific components you should worry a lot more about eating a cheeseburger and what eliminates all those chemicals from your system. The mRNA delivery system is about as close to "nothing" as you can get.
ufo 5y ago
Here's the list of excipients in the Pfizer vaccine: 1. ALC-0312 2. ALC-0159 3. 1,2-Distearoyl-sn-glycero-3-phosphocholine 4. cholesterol 5. potassium dihydrogen phosphate 6. sodium chloride 7. disodium hydrogen phosphate dihydrate 8. sucrose 9. water The first four are various lipids, used to build the lipid nanoparticles. The body can get rid of those the same way that it would get rid any other lipid. The remaining excepients are just some salts and sugar. Source: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/941452/Information_for_healthcare_professionals.pdf https://assets.publishing.service.gov.uk/government/uploads/...
AnimalMuppet 5y ago
I think that's kind of irrelevant, since those bits aren't the part that were causing concern. Nobody's worried that the part that stabilizes it for storage is going to "create a new humanoid race". That's purely based on (a misunderstanding of) the mRNA.
- throwawaysea 5y ago
  I wasn’t asking out of that same motivation. I was just wondering how true it is that the body gets rid of all the components of the vaccine and simply retains the benefit of antibodies with no “vaccine remnants”.
  - AnimalMuppet 5y ago
    Ah. It is an interesting question, I admit.

lamontcg 5y ago

The lipid nanoparticle is just lipids. Unless you happen to have an allergic reaction to the specific components you should worry a lot more about eating a cheeseburger and what eliminates all those chemicals from your system. The mRNA delivery system is about as close to "nothing" as you can get.

ufo 5y ago

Here's the list of excipients in the Pfizer vaccine: 1. ALC-0312 2. ALC-0159 3. 1,2-Distearoyl-sn-glycero-3-phosphocholine 4. cholesterol 5. potassium dihydrogen phosphate 6. sodium chloride 7. disodium hydrogen phosphate dihydrate 8. sucrose 9. water The first four are various lipids, used to build the lipid nanoparticles. The body can get rid of those the same way that it would get rid any other lipid. The remaining excepients are just some salts and sugar. Source: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/941452/Information_for_healthcare_professionals.pdf https://assets.publishing.service.gov.uk/government/uploads/...

AnimalMuppet 5y ago

I think that's kind of irrelevant, since those bits aren't the part that were causing concern. Nobody's worried that the part that stabilizes it for storage is going to "create a new humanoid race". That's purely based on (a misunderstanding of) the mRNA.

throwawaysea 5y ago
I wasn’t asking out of that same motivation. I was just wondering how true it is that the body gets rid of all the components of the vaccine and simply retains the benefit of antibodies with no “vaccine remnants”.
- AnimalMuppet 5y ago
  Ah. It is an interesting question, I admit.