5 ms·

There are two variants of the vaccine: One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune s

There are two variants of the vaccine: One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune system find this protein out and make antibodies. The other contains instead a partially destroyed viruses which trains the immune system directly on all their parts - the shell, the spikes, etc. I don't remember which company makes which kind but both are in production.

abracadaniel 5y ago
The mRNA vaccines don't produce the entire spike protein, just a portion of it in order to target the antibodies towards that specific portion of the spike.
- nielsbot 5y ago
  How much of the spike protein is coded for?
  - mike_hearn 5y ago
    Almost all of it except the part where it joins to the rest of the virus, where it's been modified to give it structural stability and stop it collapsing.
AareyBaba 5y ago
Your insights are not entirely correct. There are more than two types of covid vaccines. Coronavirus Vaccines - An Introduction by JAMA is a good starting point. https://www.youtube.com/watch?v=KMc3vL_MIeo https://www.youtube.com/watch?v=KMc3vL_MIeo COVID-19 Vaccines goes into greater detail. https://www.youtube.com/watch?v=35Idb_lCU4o https://www.youtube.com/watch?v=35Idb_lCU4o
rolph 5y ago
the "partially destroyed" virus is not a covid virus. example the johnson&johnson vaccine [a vector vaccine] is composed of attenuated [part destroyed] human adenovirus [thus non reproductive] that has an insert of conformationaly stabilized spike sequence. this makes ease of shipping and handling, but lacks good efficacy if you are immune to the adenovirus
- Gibbon1 5y ago
  I think the J&J vaccine uses an adenovirus that can't reproduce in human cells. It's missing something or other it need to reproduce and only grows in a specialized cell culture.
  - rolph 5y ago
    yes you have it right.
zoomablemind 5y ago
Chinese vaccine (SinoVac, CoronaVac) uses an inactivated whole SARS-CoV-2 virus. https://www.medicalnewstoday.com/articles/covid-19-how-do-inactivated-vaccines-work https://www.medicalnewstoday.com/articles/covid-19-how-do-in... "... In an inactivated vaccine, the pathogen is killed or modified in such a way that it is unable to replicate. It cannot cause disease and is, therefore, suitable for those with a compromised immune system. The inactivation step usually involves heat, radiation, or chemicals to destroy the pathogen’s genetic material, which stops it from replicating. Inactivated vaccines can trigger a strong immune reaction, but it is usually not as strong as the reaction that live attenuated vaccines can produce. Due to this, a person may need booster shots to ensure ongoing protection. The COVID-19 vaccines that Sinovac, Sinopharm, and Bharat Biotech have developed are inactivated vaccines. ..."

abracadaniel 5y ago

The mRNA vaccines don't produce the entire spike protein, just a portion of it in order to target the antibodies towards that specific portion of the spike.

nielsbot 5y ago
How much of the spike protein is coded for?
- mike_hearn 5y ago
  Almost all of it except the part where it joins to the rest of the virus, where it's been modified to give it structural stability and stop it collapsing.

AareyBaba 5y ago

Your insights are not entirely correct. There are more than two types of covid vaccines. Coronavirus Vaccines - An Introduction by JAMA is a good starting point. https://www.youtube.com/watch?v=KMc3vL_MIeo https://www.youtube.com/watch?v=KMc3vL_MIeo COVID-19 Vaccines goes into greater detail. https://www.youtube.com/watch?v=35Idb_lCU4o https://www.youtube.com/watch?v=35Idb_lCU4o

rolph 5y ago

the "partially destroyed" virus is not a covid virus. example the johnson&johnson vaccine [a vector vaccine] is composed of attenuated [part destroyed] human adenovirus [thus non reproductive] that has an insert of conformationaly stabilized spike sequence. this makes ease of shipping and handling, but lacks good efficacy if you are immune to the adenovirus

Gibbon1 5y ago
I think the J&J vaccine uses an adenovirus that can't reproduce in human cells. It's missing something or other it need to reproduce and only grows in a specialized cell culture.
- rolph 5y ago
  yes you have it right.

zoomablemind 5y ago

Chinese vaccine (SinoVac, CoronaVac) uses an inactivated whole SARS-CoV-2 virus. https://www.medicalnewstoday.com/articles/covid-19-how-do-inactivated-vaccines-work https://www.medicalnewstoday.com/articles/covid-19-how-do-in... "... In an inactivated vaccine, the pathogen is killed or modified in such a way that it is unable to replicate. It cannot cause disease and is, therefore, suitable for those with a compromised immune system. The inactivation step usually involves heat, radiation, or chemicals to destroy the pathogen’s genetic material, which stops it from replicating. Inactivated vaccines can trigger a strong immune reaction, but it is usually not as strong as the reaction that live attenuated vaccines can produce. Due to this, a person may need booster shots to ensure ongoing protection. The COVID-19 vaccines that Sinovac, Sinopharm, and Bharat Biotech have developed are inactivated vaccines. ..."