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> How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart? As far as I understand it, the vaccine doesn't work like th
by EMM_386 5y ago
> How long do spike proteins (SARS-CoV-2 or vaccine created) hang out if they make it to the heart?
As far as I understand it, the vaccine doesn't work like this. It tells your immune system "hey this is what a SARS-CoV-2 spike protein looks like, attack it if you see it".
So the vaccine wouldn't cause the heart damage, the vaccine does (intentionally) ramp up your immune system to learn about this new threat, which it will then attack. It doesn't bind to ACE2, it teaches your immune system to look for bad things that can.
If there is still Covid in your heart due to prior exposure, your immune system is going to go there to assist. This would cause inflammation, but intentionally. As you noted, this immune system response is correct behavior.
So that's a long way of saying the inflammation is from the virus, not the vaccine. That's why I was thinking this may only occur in vaccinated individuals who had prior exposure to Covid.
- sjg007 5y agoThe covid spike protein binds ace2 so the immune response to bind the spike could bind ace2 as well. Normally this is mitigated by a self selection filter but it is not out of the question that you could develop an autoimmune response.
- cma 5y agoThe spike protien binds to ace2 receptors, so the immune response may be more likely to bind to ACE2, which also binds to ace2 receptors, but that isn't a given because the part on the spile the immune response targets don't have to themselves match with parts of ACE2.
- nielsbot 5y agoWould it? My naive guess is that the immune response is an anti-ACE2 match. So it would bind to COVID spike protein, not the ACE2 receptor.
- loa_in_ 5y agoThere are two variants of the vaccine: One is mRNA (?) variant that gets into your cells and makes them produce just the spike protein. This lets your immune system find this protein out and make antibodies. The other contains instead a partially destroyed viruses which trains the immune system directly on all their parts - the shell, the spikes, etc. I don't remember which company makes which kind but both are in production.
- abracadaniel 5y agoThe mRNA vaccines don't produce the entire spike protein, just a portion of it in order to target the antibodies towards that specific portion of the spike.
- nielsbot 5y agoHow much of the spike protein is coded for?
- mike_hearn 5y agoAlmost all of it except the part where it joins to the rest of the virus, where it's been modified to give it structural stability and stop it collapsing.
- AareyBaba 5y agoYour insights are not entirely correct. There are more than two types of covid vaccines. Coronavirus Vaccines - An Introduction by JAMA is a good starting point. https://www.youtube.com/watch?v=KMc3vL_MIeo https://www.youtube.com/watch?v=KMc3vL_MIeo COVID-19 Vaccines goes into greater detail. https://www.youtube.com/watch?v=35Idb_lCU4o https://www.youtube.com/watch?v=35Idb_lCU4o
- rolph 5y agothe "partially destroyed" virus is not a covid virus. example the johnson&johnson vaccine [a vector vaccine] is composed of attenuated [part destroyed] human adenovirus [thus non reproductive] that has an insert of conformationaly stabilized spike sequence. this makes ease of shipping and handling, but lacks good efficacy if you are immune to the adenovirus
- Gibbon1 5y agoI think the J&J vaccine uses an adenovirus that can't reproduce in human cells. It's missing something or other it need to reproduce and only grows in a specialized cell culture.