3 ms·
Hi, some further information the following day! The 115 references you mention are for the entire Ivermectin WP page. There are only three related to COVID, a
by wrycoder 5y ago
Hi, some further information the following day!
The 115 references you mention are for the entire Ivermectin WP page. There are only three related to COVID, and two of those are obviously biased reportage from the popular press. The single pertinent reference left is
https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111678 https://ebm.bmj.com/content/early/2021/05/26/bmjebm-2021-111...
which is a well-warranted complaint regarding the chaotic nature of the current literature and clinical trials.
The article you cited was behind a paywall, but I was able to get a copy through my university. It contains a warning from the FDA not to use veterinary grade ivermectin to treat COVID, especially without a physician's supervision. That's certainly good advice.
Secondly, there are several letters that discuss the early Caly, et. al. paper regarding in vitro use of ivermectin on SARS-Cov-2 and the dosage levels involved. The point is made that, "Ivermectin's key direct target in mammalian cells is a not a viral component, but a host protein important in intracellular transport; the fact that it is a host-directed agent (HDA) is almost certainly the basis of its broad-spectrum activity against a number of different RNA viruses in vitro. The way a HDA can reduce viral load is by inhibiting a key cellular process that the virus hijacks to enhance infection by suppressing the host antiviral response."
The very great difference between the in vitro dosage level and a clinically effective dosage level is discussed on the third page of this recent article:
https://americasfrontlinedoctors.org/files/review-of-the-emerging-evidence-demonstrating-the-efficacy-of-ivermectin-in-the-prophylaxis-and-treatment-of-covid-19/ https://americasfrontlinedoctors.org/files/review-of-the-eme...
We are in violent agreement about not using the in vitro dose level in vivo! (I think that's a strawman, no one is suggesting that.)
I'd also recommend the following recent article discussing actual clinical experience, written by a physician who makes every attempt to remain neutral and science-based:
https://sebastianrushworth.com/2021/05/09/update-on-ivermectin-for-covid-19/ https://sebastianrushworth.com/2021/05/09/update-on-ivermect...