4 ms·
> the vaccine version of spike has been stabilized so as to remain in the default state resulting in a bias toward neutralizing antibodies. I'm not strong in m
by f6v 5y ago
> the vaccine version of spike has been stabilized so as to remain in the default state resulting in a bias toward neutralizing antibodies.
I'm not strong in molecular immunology. Does that also hold for the mRNA vaccines? Or only those that ship the spike protein itself?
- rolph 5y agoyes this is the case for the vaccines, and any synthetic protien based vaccine that is to come. there is a manner of inserting a couple of extra amino acids at a crucial location that will prevent the change of state when cleavage is activated. This leaves it "open" to binding at points required for cellular entry. this took the better part of 12 years to understand the virus to the point that we knew how to stabilize tthe spike.