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For anyone unfamiliar with dengue, among its more notorious aspects is that repeated infections over a victim’s lifetime can make its impact worse. https://en.

For anyone unfamiliar with dengue, among its more notorious aspects is that repeated infections over a victim’s lifetime can make its impact worse. https://en.wikipedia.org/wiki/Dengue_fever https://en.wikipedia.org/wiki/Dengue_fever Very happy to hear this news. Selfishly, with a warming climate the impact of the virus is likely to spread, and generally the more tropical diseases we can wipe out the better.

Vecr 5y ago
The vaccine causes Antibody-Dependent Enhancement (ADE) as well as natural infection [0], so the situation as a whole is not very good. [0]: https://en.wikipedia.org/wiki/Dengue_vaccine#CYD-TDV_(Dengvaxia) https://en.wikipedia.org/wiki/Dengue_vaccine#CYD-TDV_(Dengva...
krrrh 5y ago
This fact makes the stat from the article all the more alarming. > In 1970, only nine countries had faced severe dengue outbreaks, now there are up to 400 million infections a year. It amazes me to think of how relatively small the team that worked on this was in relation to the outsized benefit to humanity.
- midasuni 5y ago
  Far more people working on male pattern baldness cures
- Gibbon1 5y ago
  That's public heath in a nutshell.
  - BBC-vs-neolibs 5y ago
    as opposed to?
the_af 5y ago
> For anyone unfamiliar with dengue, among its more notorious aspects is that repeated infections over a victim’s lifetime can make its impact worse. One really minor nitpick, but I think it's different strains of dengue that get you: get infected by one, and you get resistance for that strain, but also become more susceptible to develop complications or die from a separate strain.
- travisjungroth 5y ago
  I was lucky enough to get the non-hemorrhaging type. But now if I get the hemorrhaging type it will be extra bad. So that's lame.
  - icoder 5y ago
    I thought that the hemorrhaging wasn't necessarily related to a strain, but _is_ a possible heavier outcome regardless of the order you get them in?
  - r00f 5y ago
    i had it pretty heavy, all the symptoms as by the book, but two independent labs showed that i didn't have dengue. so now i do not know if i had it or something different with very similar symptoms
    - emblaegh 5y ago
      afaik, Chikungunya and Zika can be very similar to Dengue.
    - lobocinza 5y ago
      False negatives are common when testing on the first week of symptoms. But after 1-2 weeks serology testing is accurate. My 1st exam was negative and the 2nd (after 2 weeks) was positive. There are other viruses with symptoms similar to Dengue like Zika and Chikungunya.
- icoder 5y ago
  Very relevant nitpicking! Also makes vaccination more tricky as it should ideally cover all strains to prevent the same effect.
shkkmo 5y ago
This is extremely good news. I watched my brother spend a week and a half in a hospital in a small Ecuadorian village due to a dengue infection. His fever was dangerously high for days and then his platet counts dropped so low that he was at significant risk of internal bleeding.
superasn 5y ago
Yes probably the best news I've read today. A friend got sick of it sometime back and it was one of the most harrowing experience of his life. The amount of pain is just indescribable. He had blood coming out of his gums and whatnot. Anything to eradicate this and malaria is just amazing news.
jamal-kumar 5y ago
I live in the tropics, I've gotten dengue before. Can confirm that it feels like getting run over by a bus. I actually have more fear about getting it again than I do around coronavirus. The funny thing is that me and my roommate at the time just thought we had really bad achy flus. I think we probably should have gone to the hospital in retrospect.
- lobocinza 5y ago
  I stayed the whole day in bed without eating anything in the 1st day. I ate in the whole week what I used to eat in a day. In retrospective, I learned to eat less and, in the long term, I got healthier due to it.

Vecr 5y ago

The vaccine causes Antibody-Dependent Enhancement (ADE) as well as natural infection [0], so the situation as a whole is not very good. [0]: https://en.wikipedia.org/wiki/Dengue_vaccine#CYD-TDV_(Dengvaxia) https://en.wikipedia.org/wiki/Dengue_vaccine#CYD-TDV_(Dengva...

krrrh 5y ago

This fact makes the stat from the article all the more alarming. > In 1970, only nine countries had faced severe dengue outbreaks, now there are up to 400 million infections a year. It amazes me to think of how relatively small the team that worked on this was in relation to the outsized benefit to humanity.

midasuni 5y ago
Far more people working on male pattern baldness cures
Gibbon1 5y ago
That's public heath in a nutshell.
- BBC-vs-neolibs 5y ago
  as opposed to?

the_af 5y ago

> For anyone unfamiliar with dengue, among its more notorious aspects is that repeated infections over a victim’s lifetime can make its impact worse. One really minor nitpick, but I think it's different strains of dengue that get you: get infected by one, and you get resistance for that strain, but also become more susceptible to develop complications or die from a separate strain.

travisjungroth 5y ago
I was lucky enough to get the non-hemorrhaging type. But now if I get the hemorrhaging type it will be extra bad. So that's lame.
- icoder 5y ago
  I thought that the hemorrhaging wasn't necessarily related to a strain, but _is_ a possible heavier outcome regardless of the order you get them in?
- r00f 5y ago
  i had it pretty heavy, all the symptoms as by the book, but two independent labs showed that i didn't have dengue. so now i do not know if i had it or something different with very similar symptoms
  - emblaegh 5y ago
    afaik, Chikungunya and Zika can be very similar to Dengue.
  - lobocinza 5y ago
    False negatives are common when testing on the first week of symptoms. But after 1-2 weeks serology testing is accurate. My 1st exam was negative and the 2nd (after 2 weeks) was positive. There are other viruses with symptoms similar to Dengue like Zika and Chikungunya.
icoder 5y ago
Very relevant nitpicking! Also makes vaccination more tricky as it should ideally cover all strains to prevent the same effect.

shkkmo 5y ago

This is extremely good news. I watched my brother spend a week and a half in a hospital in a small Ecuadorian village due to a dengue infection. His fever was dangerously high for days and then his platet counts dropped so low that he was at significant risk of internal bleeding.

superasn 5y ago

Yes probably the best news I've read today. A friend got sick of it sometime back and it was one of the most harrowing experience of his life. The amount of pain is just indescribable. He had blood coming out of his gums and whatnot. Anything to eradicate this and malaria is just amazing news.

jamal-kumar 5y ago

I live in the tropics, I've gotten dengue before. Can confirm that it feels like getting run over by a bus. I actually have more fear about getting it again than I do around coronavirus. The funny thing is that me and my roommate at the time just thought we had really bad achy flus. I think we probably should have gone to the hospital in retrospect.

lobocinza 5y ago
I stayed the whole day in bed without eating anything in the 1st day. I ate in the whole week what I used to eat in a day. In retrospective, I learned to eat less and, in the long term, I got healthier due to it.