2 ms·
Yes! https://www.nejm.org/doi/full/10.1056/NEJMc2032195 https://www.nejm.org/doi/full/10.1056/NEJMc2032195 Shows a slow decay in neutralizing antibody titers,
by mlyle 5y ago
Yes! https://www.nejm.org/doi/full/10.1056/NEJMc2032195 https://www.nejm.org/doi/full/10.1056/NEJMc2032195
Shows a slow decay in neutralizing antibody titers, with a greater degree of viral inhibition months later than convalescent plasma at a month.
"At day 119, the binding and neutralizing GMTs exceeded the median GMTs in a panel of 41 controls who were convalescing from Covid-19, with a median of 34 days since diagnosis (range, 23 to 54)."
Note that antibodies to all parts of the virus aren't necessarily equally beneficial, because only a few functional areas are neutralizing.
- rolph 5y agoneutralizing antibodies will give protection against cell entry to the degree they saturate the binding kinetics between receptor and ligand. non neutralizing does not mean ineffective, as ^any^ antibody is a lable that will provoke a complement based immune response, further leading to Tcell based production of antibodies that also include Ab that will bind to domains of spike that are essential to cell entry
- mlyle 5y agoSure, non-neutralizing binding antibodies are also useful. I think you maybe meant to respond to the parent of my comment. The paper shows high binding affinities and high neutralization titers in comparison to convalescent plasma.