3 ms·
the problem with live covid as the antigenic character is of course the mortality, and the morbidity risk. there is also the instability of the spike protien i
by rolph 5y ago
the problem with live covid as the antigenic character is of course the mortality, and the morbidity risk.
there is also the instability of the spike protien in its natural form. when spike is cloven at it cleavage site it changes conformation, thus there are two faces available to the immune system; the default state, the cloven prefusion state. This makes a Naturally aquired immunity biased toward opsonizing antbodies.
the vaccine version of spike has been stabilized so as to remain in the default state resulting in a bias toward neutralizing antibodies.
so neutralizing antibodies bind to the viral spike at locations that interfere with receptor docking thus ideally preventing viral entry, while the immune system operates upon the many other viral epitopes, to produce a variant array of antibodies. This gives Tcell based [longterm] immunity.
the naturally aquired immunity involves Tcell activity upon infection, but that is the risk, as virus is capable of entering the cells before immune system begins to work against it.
this is why boosting is required beyond initial vaccine dose.
and this is why i believe it would be a good idea to take a vaccine along with naturally aquired immunity due to recovery, and you can have the best of both worlds, while not relying solely on naturally based immunity.
- f6v 5y ago> the vaccine version of spike has been stabilized so as to remain in the default state resulting in a bias toward neutralizing antibodies. I'm not strong in molecular immunology. Does that also hold for the mRNA vaccines? Or only those that ship the spike protein itself?
- rolph 5y agoyes this is the case for the vaccines, and any synthetic protien based vaccine that is to come. there is a manner of inserting a couple of extra amino acids at a crucial location that will prevent the change of state when cleavage is activated. This leaves it "open" to binding at points required for cellular entry. this took the better part of 12 years to understand the virus to the point that we knew how to stabilize tthe spike.