3 ms·

>the claim is that there is no natural process that will result in the double argenine sequence. I think the claim is that it is very unlikely to happen natura

by spadez 5y ago

>the claim is that there is no natural process that will result in the double argenine sequence. I think the claim is that it is very unlikely to happen naturally, and the article makes it very clear. So I wonder why you assume that it claims "there is no natural process". And the final suggestion of the article appears NOT to be that lab leak is the final conclusion, but only that it should be the leading hypothesis among the existing ones, if one goes by science and science alone.

rolph 5y ago
i am not assuming, the claim is made very clearly multiple times through the article , and the WSJ article , has cherry picked the publication. there is no basis to the claim that 2 arginine codons adjacent to each other is a rare, engineered event, this [codon duplication]is a very common artefect of natural nucleotide repair mechanisms, also the article suffers from a deficiency of understanding, as the duplication of a lesion associated codon is also accompanied with a guide segment of nucleotide so the feature is more than just a duplicated codon. there is also the case of transversion and this has not been addressed, but could be illuminated with radio phosphorous labeling and restriction fragment analysis.
gus_massa 5y ago
> if one goes by science and science alone The press article is not very technical. The research paper is more interesting, but IIUC it is mostly about how this "furin cleavage" is very important and why it's important that is has two amino acids, but the discussion about the possible mutation to reach it is very shallow. I'd like to see an accurate model of all the known ways the virus can mutate, tweaked to model origin of the current known species of coronavirus, and then use the model to get an estimation of the origin that is impossible, and then "use science" to conclude that the handmade origin is likely.
- rolph 5y ago
  if you look around at the back story for Steven Quay, and Richard Muller, it gets interesting. https://medium.com/beingwell/dr-steven-quay-to-brief-u-s-congress-on-origin-of-the-covid-19-pandemic-ccc857d951c4 https://medium.com/beingwell/dr-steven-quay-to-brief-u-s-con... "He is the author of a book on surviving the pandemic, “Stay Safe: A Physician’s Guide to Survive Coronavirus”. He has seen his fair share of controversy during the pandemic. His book, published in June of 2020 was removed from Kindle by Amazon, hours after its launch. His outspoken views on treatments for Covid-19 have often conflicted with the official narrative. For instance, in his book, he offers the following advice for dealing with Covid-19, and it's not difficult to see why the book was removed by Amazon. One 2-minute step you can take every time you come home to kill coronavirus before it enters your lungs A quick, free home test for COVID-19 that is as good as the FDA-approved nasal swab The one exercise you won’t learn in the gym that can save your life How NOT to die of COVID-19 (Make your lungs younger) What to do if you have early-stage COVID-19 so that you can stay out of the hospital The #1 most effective way to prevent the spread of coronavirus as we reopen society (Hint: it’s the one thing the CDC said was “NOT effective” when coronavirus hit the U.S.) Why a vaccine won’t be the solution, and what YOU can do to protect yourself, now and in the future What to eat and drink (and what to avoid), so you can prevent and beat this coronavirus The best supplements I have found from clinical trial research for immune health during this pandemic The coronavirus’ “Diabolic Trait” and how it helped the virus spread so fast An easy DIY step that takes your face mask from a viral barrier to a virus killer, giving you over 100-times the protection of an untreated mask The one blood test to ask for if you are hospitalized that can keep you off a ventilator Three steps to take to thrive during the next epidemic Learn about gain-of-function research and why we must ban it to prevent future pandemics"

by spadez 5y ago

rolph 5y ago

i am not assuming, the claim is made very clearly multiple times through the article , and the WSJ article , has cherry picked the publication. there is no basis to the claim that 2 arginine codons adjacent to each other is a rare, engineered event, this [codon duplication]is a very common artefect of natural nucleotide repair mechanisms, also the article suffers from a deficiency of understanding, as the duplication of a lesion associated codon is also accompanied with a guide segment of nucleotide so the feature is more than just a duplicated codon. there is also the case of transversion and this has not been addressed, but could be illuminated with radio phosphorous labeling and restriction fragment analysis.

gus_massa 5y ago

> if one goes by science and science alone The press article is not very technical. The research paper is more interesting, but IIUC it is mostly about how this "furin cleavage" is very important and why it's important that is has two amino acids, but the discussion about the possible mutation to reach it is very shallow. I'd like to see an accurate model of all the known ways the virus can mutate, tweaked to model origin of the current known species of coronavirus, and then use the model to get an estimation of the origin that is impossible, and then "use science" to conclude that the handmade origin is likely.

rolph 5y ago
if you look around at the back story for Steven Quay, and Richard Muller, it gets interesting. https://medium.com/beingwell/dr-steven-quay-to-brief-u-s-congress-on-origin-of-the-covid-19-pandemic-ccc857d951c4 https://medium.com/beingwell/dr-steven-quay-to-brief-u-s-con... "He is the author of a book on surviving the pandemic, “Stay Safe: A Physician’s Guide to Survive Coronavirus”. He has seen his fair share of controversy during the pandemic. His book, published in June of 2020 was removed from Kindle by Amazon, hours after its launch. His outspoken views on treatments for Covid-19 have often conflicted with the official narrative. For instance, in his book, he offers the following advice for dealing with Covid-19, and it's not difficult to see why the book was removed by Amazon. One 2-minute step you can take every time you come home to kill coronavirus before it enters your lungs A quick, free home test for COVID-19 that is as good as the FDA-approved nasal swab The one exercise you won’t learn in the gym that can save your life How NOT to die of COVID-19 (Make your lungs younger) What to do if you have early-stage COVID-19 so that you can stay out of the hospital The #1 most effective way to prevent the spread of coronavirus as we reopen society (Hint: it’s the one thing the CDC said was “NOT effective” when coronavirus hit the U.S.) Why a vaccine won’t be the solution, and what YOU can do to protect yourself, now and in the future What to eat and drink (and what to avoid), so you can prevent and beat this coronavirus The best supplements I have found from clinical trial research for immune health during this pandemic The coronavirus’ “Diabolic Trait” and how it helped the virus spread so fast An easy DIY step that takes your face mask from a viral barrier to a virus killer, giving you over 100-times the protection of an untreated mask The one blood test to ask for if you are hospitalized that can keep you off a ventilator Three steps to take to thrive during the next epidemic Learn about gain-of-function research and why we must ban it to prevent future pandemics"