5 ms·
The Science Suggests a Wuhan Lab Leak
- haspoken 5y agohttp://archive.is/f6iG6 http://archive.is/f6iG6
- rolph 5y agohttps://en.wikipedia.org/wiki/Positive-strand_RNA_virus#Recombination https://en.wikipedia.org/wiki/Positive-strand_RNA_virus#Reco...
- jdlyga 5y agoThis is an opinion piece
- cheph 5y agoCorrect. The thing is though, so was all the "news" that asserted that the lab leak theory is a conspiracy theory, or that the only possibility is a natural origin, or that we should ban everyone from the internet who suggests lab leak is possible. Conjecture is conjecture, but "this is conjecture" is not a refutation of said conjecture. And banning all refutations of conjecture such as "this was definitely natural and any suggestion that it is not is a racist conspiracy theory" is also not refutation.
- rolph 5y agoAdenosine often converts to a pyrimidine spontaneously by way of non-synthetic [i.e naturally ocurring] means https://en.wikipedia.org/wiki/Transversion https://en.wikipedia.org/wiki/Transversion https://www.mun.ca/biology/scarr/Transitions_vs_Transversions.html https://www.mun.ca/biology/scarr/Transitions_vs_Transversion... https://www.youtube.com/watch?v=BOQeRsxYdA8 https://www.youtube.com/watch?v=BOQeRsxYdA8
- gus_massa 5y agoWhy is this relevant for the CGGCGG sequence? [Disclaimer: I'm very skeptical of the claims of the post, but it's too far away of my area to write something more detailed. I guess you understand more about this.]
- rolph 5y agothe claim is that there is no natural process that will result in the double argenine sequence. Adenine or adenosine can spontaneously [naturally] convert to a guanidine, or cytosine. in addition recombination of two different RNA strands often occurs with RNA virus this is often evidenced by doubling of codons, often due to a "sticky end" break in the RNA strand. thus something like AGGCGG may naturally and spontaneously transvert to CGGCGG thanks for your interest gus have a look here re: sticky ends https://en.wikipedia.org/wiki/Sticky_and_blunt_ends#Overhangs_and_sticky_ends https://en.wikipedia.org/wiki/Sticky_and_blunt_ends#Overhang... sticky ends are most common with DNA however this is also an occurence with RNA complexed to double strand in physiological conditions. [ADNDM] it may be confusing to examine without this little bit; DNA is constructed of base pairs A-T and G-C and is double stranded as a central tendency RNA is composed of a sequence of A, U [uracil], G, and C but is often interpreted as a DNA sequence that would generate the RNA, espescially when speaking of [or working with] mRNA. RNA is not obligated to double strandedness however will form double strand complexes as part of its funtionality.
- gus_massa 5y agoIs there a famous case about duplication of a codon in an insertion? Looking at the paper that is linked in the article, the double codon is in Figure 1B. I really don't understand why that is a good alignment, the rest of the sequence looks very different. Is that usual or I'm missing something important? [I have an specialization in Chemistry during Secondary School, so I can distinguish polar and not polar and weird amino acids just looking at the formulas, but I never remember the names and I don't know by heat weird reactions.]
- 5y ago
- known 5y agoNo evidence = No crime