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Which other Coronaviruses have a furin cleavage site using arginine? Which other coronaviruses even have arginine in their proteome?
by eutropia 5y ago
Which other Coronaviruses have a furin cleavage site using arginine?
Which other coronaviruses even have arginine in their proteome?
- shellfishgene 5y agoWhy would coronaviruses not have arginine?
- eutropia 5y agoSorry, I was being hasty (replying in too many locations to produce a good and thoughtful response -- instead I produced a factually incorrect one) Damns my credibility a bit, doesn't it? Well, I should have more accurately mentioned that the FCS insertion (CT CCT CGG CGG G (PRRA)) Is rather unusual by betacoronavirus standards in that arginine is not typically coded as CGG (~5% of the time), and that RR coded for as CGG-CGG has not been seen in any betacoronavirus to date. I have more in another comment: https://news.ycombinator.com/item?id=27393013 https://news.ycombinator.com/item?id=27393013 But my quality quotient on this thread has been all over the place. Probably too invested in getting people to consider the possibility of the lab leak as most probable until we see an animal population to prove the natural hypothesis.