4 ms·

> Why? You've artificially limited the number of possible labs to those doing bioweapon research. If this isn't your claim there is no reason to do so and if t

by flukus 5y ago

> Why? You've artificially limited the number of possible labs to those doing bioweapon research. If this isn't your claim there is no reason to do so and if there are more labs studying coronavirus it's far less coincidental.

kaesar14 5y ago
The lab wasn’t conducting bioweapon research. Gain of function research isn’t to create a bioweapon, nominally. It’s to examine the behavior of viruses under manipulation in order to better understand how we can respond to them given an outbreak. It’s not nefarious by nature, though it does seem like its usefulness hasn’t panned out as was thought. But again, you really should read the article to understand what gain of function research is instead of insinuating I said COVID was a bioweapon.
tripletao 5y ago
There is zero evidence that anyone, anywhere in the world was working to develop SARS-like bioweapons. The gain-of-function research in question would have been basic research, intended to develop more dangerous variants of the viruses in order to predict future pandemic emergence, develop more universal vaccines, etc. I believe this research was reckless and should never have been funded (by the USA!) or permitted, even considering only what they knew at the time. It wasn't malicious, though. In any case, beyond gain-of-function, the WIV and Wuhan CDC also had the biggest program in the world to sample novel SARS-like coronaviruses from nature, from remote bat caves that no other humans had any reason to enter. https://www.washingtonpost.com/world/asia_pacific/coronavirus-bats-china-wuhan/2021/06/02/772ef984-beb2-11eb-922a-c40c9774bc48_story.html https://www.washingtonpost.com/world/asia_pacific/coronaviru... If SARS-CoV-2 is a naturally-evolved virus accidentally released by scientists, then Wuhan is the obvious place for it to emerge. That could have been directly from a lab, or a researcher could have become infected on a sampling trip, traveled home from the sampling sites (~900 miles away, to be clear; Wuhan was not an expected natural spillover region), and seeded the infection there. None of this is anywhere close to proven, but the previous dismissal of any unnatural origin as a "conspiracy theory" was an outrageous, unscientific smear.
- wearywanderer 5y ago
  > There is zero evidence that anyone, anywhere in the world was working to develop SARS-like bioweapons How do I square that with this claim from the article? > Eleven of its 23 coauthors worked for the Academy of Military Medical Sciences, the Chinese army’s medical research institute. Using the gene-editing technology known as CRISPR, the researchers had engineered mice with humanized lungs, then studied their susceptibility to SARS-CoV-2. As the NSC officials worked backward from the date of publication to establish a timeline for the study, it became clear that the mice had been engineered sometime in the summer of 2019, before the pandemic even started. The NSC officials were left wondering: Had the Chinese military been running viruses through humanized mouse models, to see which might be infectious to humans?" What this describes seems like it could be circumstantial evidence of the PLA developing bioweapons. Certainly it isn't proof of anything, and as evidence it's not very strong. But I wouldn't call it 'zero.'
  - tripletao 5y ago
    "Running viruses through humanized mouse models" is a pretty normal (though frightening) part of virology. For example, Ralph Baric was doing it back in 2005: https://www.pnas.org/content/102/23/8073 https://www.pnas.org/content/102/23/8073 So if the Chinese military had in fact been doing this, I'd guess it was just basic research, in the same way that lots of American basic research links back to DARPA. Of course they fund it because they believe there might be a military application, but I see no reason to think that application would be bioweapons (vs. the same kind of beneficial applications described in the open literature).
    - Throwawayaerlei 5y ago
      Offensive bioweapons researchers don't publish their results in scientific journals.
      - tripletao 5y ago
        Perhaps "no evidence" would have been better phrasing than "no reason"? I do think it's possible that some Chinese (or American, or British, or ...) military officer has at some point wondered if coronaviruses would make good bioweapons, but there's still no evidence. They don't seem like obvious candidates to me, though. Both SARS v1 and SARS-CoV-2 show unpredictable, stochastic person-to-person spread, via super-spreader events. For a bioweapon that would ideally infect all the enemy but no one else, that's the last thing you want, hard to reliably get started and hard to reliably stop once it starts. So that reinforces my belief that if SARS-CoV-2 was of unnatural origin, it was almost certainly an accident during basic research.

by flukus 5y ago

kaesar14 5y ago

The lab wasn’t conducting bioweapon research. Gain of function research isn’t to create a bioweapon, nominally. It’s to examine the behavior of viruses under manipulation in order to better understand how we can respond to them given an outbreak. It’s not nefarious by nature, though it does seem like its usefulness hasn’t panned out as was thought. But again, you really should read the article to understand what gain of function research is instead of insinuating I said COVID was a bioweapon.

tripletao 5y ago

There is zero evidence that anyone, anywhere in the world was working to develop SARS-like bioweapons. The gain-of-function research in question would have been basic research, intended to develop more dangerous variants of the viruses in order to predict future pandemic emergence, develop more universal vaccines, etc. I believe this research was reckless and should never have been funded (by the USA!) or permitted, even considering only what they knew at the time. It wasn't malicious, though. In any case, beyond gain-of-function, the WIV and Wuhan CDC also had the biggest program in the world to sample novel SARS-like coronaviruses from nature, from remote bat caves that no other humans had any reason to enter. https://www.washingtonpost.com/world/asia_pacific/coronavirus-bats-china-wuhan/2021/06/02/772ef984-beb2-11eb-922a-c40c9774bc48_story.html https://www.washingtonpost.com/world/asia_pacific/coronaviru... If SARS-CoV-2 is a naturally-evolved virus accidentally released by scientists, then Wuhan is the obvious place for it to emerge. That could have been directly from a lab, or a researcher could have become infected on a sampling trip, traveled home from the sampling sites (~900 miles away, to be clear; Wuhan was not an expected natural spillover region), and seeded the infection there. None of this is anywhere close to proven, but the previous dismissal of any unnatural origin as a "conspiracy theory" was an outrageous, unscientific smear.

wearywanderer 5y ago
> There is zero evidence that anyone, anywhere in the world was working to develop SARS-like bioweapons How do I square that with this claim from the article? > Eleven of its 23 coauthors worked for the Academy of Military Medical Sciences, the Chinese army’s medical research institute. Using the gene-editing technology known as CRISPR, the researchers had engineered mice with humanized lungs, then studied their susceptibility to SARS-CoV-2. As the NSC officials worked backward from the date of publication to establish a timeline for the study, it became clear that the mice had been engineered sometime in the summer of 2019, before the pandemic even started. The NSC officials were left wondering: Had the Chinese military been running viruses through humanized mouse models, to see which might be infectious to humans?" What this describes seems like it could be circumstantial evidence of the PLA developing bioweapons. Certainly it isn't proof of anything, and as evidence it's not very strong. But I wouldn't call it 'zero.'
- tripletao 5y ago
  "Running viruses through humanized mouse models" is a pretty normal (though frightening) part of virology. For example, Ralph Baric was doing it back in 2005: https://www.pnas.org/content/102/23/8073 https://www.pnas.org/content/102/23/8073 So if the Chinese military had in fact been doing this, I'd guess it was just basic research, in the same way that lots of American basic research links back to DARPA. Of course they fund it because they believe there might be a military application, but I see no reason to think that application would be bioweapons (vs. the same kind of beneficial applications described in the open literature).
  - Throwawayaerlei 5y ago
    Offensive bioweapons researchers don't publish their results in scientific journals.
    - tripletao 5y ago
      Perhaps "no evidence" would have been better phrasing than "no reason"? I do think it's possible that some Chinese (or American, or British, or ...) military officer has at some point wondered if coronaviruses would make good bioweapons, but there's still no evidence. They don't seem like obvious candidates to me, though. Both SARS v1 and SARS-CoV-2 show unpredictable, stochastic person-to-person spread, via super-spreader events. For a bioweapon that would ideally infect all the enemy but no one else, that's the last thing you want, hard to reliably get started and hard to reliably stop once it starts. So that reinforces my belief that if SARS-CoV-2 was of unnatural origin, it was almost certainly an accident during basic research.