Of course, I am talking about "recreational" Ketamine usage (not controlled by a physician or similar), but: I have lost two friends to it and another one went

Of course, I am talking about "recreational" Ketamine usage (not controlled by a physician or similar), but: I have lost two friends to it and another one went to the hospital multiple times. Considering that I am just one data point, I find that these are a lot of connections to people who had fatal events due to ketamine usage. This is not including the people I know who had a mild and severe addiction. Since you mention daily dose requirements, I would add that that is really the health risk here, since you would need double or triple the dosage (to get the psychoactive effects) after just a couple weeks of daily usage and it keeps increasing. This really puts a strain on your body until it will just fail to work anymore. Also if you use it in sub-anasthetic doses it can really fuck your head after a while and lead to dissociative episodes or even disorders as well as anxiety and paranoia and a loss of the `sense of reality` (like most other drugs do). Additionally it should be mentioned that - the neurotoxicity of Ketamine is not really explored - most street `Ketamine` is not that at all but often research chemicals which are even less explored health and addiction wise