3 ms·
Yes, the patch is coated with the actual spike protein, with some modifications: > The HD-MAP is a 1 x 1 cm solid polymer microprojection array containing 5,00
by flobosg 5y ago
Yes, the patch is coated with the actual spike protein, with some modifications:
> The HD-MAP is a 1 x 1 cm solid polymer microprojection array containing 5,000 projections of 250 μm in length. Vaccine is coated onto the microprojections via a nitrogen-jet-based drying process before application to the skin at a velocity of 18-20 m/s via a spring-loaded applicator.
> Here, we explore HD-MAP delivery of a subunit vaccine candidate –a recombinant SARS-CoV-2 spike glycoprotein, termed HexaPro which has been stabilized in its prefusion conformation by removal of the furin cleavage site and the inclusion of six stabilizing proline mutations