I do that for my work machine which is a MacBook Pro. You still need to install most GUI apps through the normal non-Nix procedure. You also won't be able to

I do that for my work machine which is a MacBook Pro. You still need to install most GUI apps through the normal non-Nix procedure. You also won't be able to use the Git module in home manager since that will use a version of Git that doesn't understand some MacOS specific customizations, mostly surrounding Keychain if i recall correctly. Most packages just work on MacOS but it's not a first class citizen and there are always more packages broken for Darwin than Linux. But I'll say it again, I tend to dabble in plenty of programming languages and often run software that's a bit off the beaten path and Home Manager and Nix on MacOS work 95% of the time for me.