3 ms·
What's with the exact 450 mcg recommendation? What happens if I take more?
by Traubenfuchs 5y ago
What's with the exact 450 mcg recommendation?
What happens if I take more?
- raducu 5y agoThere was a MIT study that the optimal doaage for sleep is around 300mcg. The body produces about 30mcg of melatonin afik, and the oral bioavailability of melatonin is about 10% so, the math works out. More might produce excessive grogginess after you wake up, and in my experience it leads to fast tolerance -- so it doesn't work; 300-450mcg works in perpetuity for me.
- zdragnar 5y agoI get really bad restless legs on enough of it- so I get groggy, but end up taking longer to sleep and feel less rested after.
- vidarh 5y agoThe precise dose that works for you may vary, but a significant sign you've taken too much is feeling really tired and groggy the following day. For me up to about 1mg seems to work fine but I've not used it enough to see how well it works below that.