4 ms·
Such as what substances? And are they available in supplements?
by airesearcher 5y ago
Such as what substances? And are they available in supplements?
- The_rationalist 5y agoThere are many but the most studied one is skq1. It is marketed as eye drops for slowing age related eye diseases such as macular degeneration. It is also marketed as cosmetics to be applied on the skin as an anti wrinkle agent. Of course those uses are not enough geroprotective. The oral pill is in the work and will very probably be the breakthrough of the century though, it will take ~a decade before being FDA approved. However indeed the currently marketed cosmetics are the same active substance and can be off-label ingested orally (or sublingually). Anybody doing that should read the pubmed papers about Skq1 in order to make an informed decision. The other contender is Fullerene C60 which is bioavailable when diluted in oil (e.g olive oil) however it doesn't cross the blood brain barrier and hence won't stop your current neurodegeneration.
- dozenmattr 5y agoTheres lots of info about C60 on Longecity but I think that forum is slowly dying now. Could you share where you're reading info about SkQ1? Is it another life extension forum?
- swader999 5y agoBest source to purchase?
- analyte123 5y agoMitoQ is in the same class as SkQ1 and is already marketed as a pill. Both are made up of an antioxidant anion and a phosphonium cation for getting into mitochondria. However, a rare controlled study against using a random inert anion with the same mitochondrial penetrator shows similar effects as the purported geroprotectors [1] suggesting that nobody has any idea how these molecules work to the extent they work at all. But it’s definitely an interesting area of research. [1] https://pubmed.ncbi.nlm.nih.gov/31139092/ https://pubmed.ncbi.nlm.nih.gov/31139092/