5 ms·

If leaders and strategists around the world could take one single lesson from the Covid pandemic, it should be that you must never, never underestimate the powe

by marvin 5y ago

If leaders and strategists around the world could take one single lesson from the Covid pandemic, it should be that you must never, never underestimate the power of mental inertia and the status quo. It leaves all but an elite few in the dust when reality suddenly changes in what's perceived to be an instant. Most normally competent people will behave as complete morons for the 6-12 months it takes them to understand the new reality. Of course, reality has been changing for a long time, but in principle there's still time to react when it becomes obvious to well-placed observers. I'm sure that an organization that's able to internalize that lesson will have an immense strategic advantage in a conflict against a peer force. Whether that be a virus, a military adversary or a competing industrial entity.

nojokes 5y ago
The West could have ended the local epidemic in about 1/2 year with the help of mRNA vaccines. While medical system is patting themselves on the shoulder, they completely missed the opportunity. The missed actions were a) human challenge studies to tremendously speed up the validation of efficacy and b) war time like effort to invest into vaccine production facilities. Human challenge studies were rejected by ethical committees - like the risk of health of few tens of thousands were greater than the life of millions. I am not sure what prevented the proper scale up of the production.
- seoaeu 5y ago
  The mRNA vaccines were approved back in December and yet six months later they've only made enough doses for a couple hundred million people. What evidence do you have that a "war time like effort" could have ramped up production wildly faster than what they achieved? It isn't like there are any unused vaccine factories or production machines just lying around, and there'd certainly be no shortage of eager investors fund increasing capacity faster if that was possible
  - nojokes 5y ago
    War time effort = create new vaccine factories when needed, share the know-how, do what ever necessary. And when did they start to ramp up the production?
    - seoaeu 5y ago
      Moderna started ramping up back in August [0], two and a half months after they'd dosed the first stage 1 trial participant [1]. I'm just really not convinced that their scaling up was that bad that they could have done it six months faster. There are real bottlenecks involved, and some extremely specialized equipment. Not to mention that even in WW2, the United States' new naval shipyards took something like 9 months of ramping up before they launched their first ship. [0]: https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-supply-agreement-us-government-initial-100 https://investors.modernatx.com/news-releases/news-release-d... [1]: https://investors.modernatx.com/news-releases/news-release-details/moderna-completes-enrollment-phase-2-study-its-mrna-vaccine https://investors.modernatx.com/news-releases/news-release-d...
      - nojokes 5y ago
        And they should already have started in spring or before and share the knowledge to others how to make mRNA vaccines.

by marvin 5y ago

nojokes 5y ago

The West could have ended the local epidemic in about 1/2 year with the help of mRNA vaccines. While medical system is patting themselves on the shoulder, they completely missed the opportunity. The missed actions were a) human challenge studies to tremendously speed up the validation of efficacy and b) war time like effort to invest into vaccine production facilities. Human challenge studies were rejected by ethical committees - like the risk of health of few tens of thousands were greater than the life of millions. I am not sure what prevented the proper scale up of the production.

seoaeu 5y ago
The mRNA vaccines were approved back in December and yet six months later they've only made enough doses for a couple hundred million people. What evidence do you have that a "war time like effort" could have ramped up production wildly faster than what they achieved? It isn't like there are any unused vaccine factories or production machines just lying around, and there'd certainly be no shortage of eager investors fund increasing capacity faster if that was possible
- nojokes 5y ago
  War time effort = create new vaccine factories when needed, share the know-how, do what ever necessary. And when did they start to ramp up the production?
  - seoaeu 5y ago
    Moderna started ramping up back in August [0], two and a half months after they'd dosed the first stage 1 trial participant [1]. I'm just really not convinced that their scaling up was that bad that they could have done it six months faster. There are real bottlenecks involved, and some extremely specialized equipment. Not to mention that even in WW2, the United States' new naval shipyards took something like 9 months of ramping up before they launched their first ship. [0]: https://investors.modernatx.com/news-releases/news-release-details/moderna-announces-supply-agreement-us-government-initial-100 https://investors.modernatx.com/news-releases/news-release-d... [1]: https://investors.modernatx.com/news-releases/news-release-details/moderna-completes-enrollment-phase-2-study-its-mrna-vaccine https://investors.modernatx.com/news-releases/news-release-d...
    - nojokes 5y ago
      And they should already have started in spring or before and share the knowledge to others how to make mRNA vaccines.