There's no clear, one-size-fits-all answer to this. The antidepressant effects of ketamine seem to be more short-lived (though not in everyone... for some ther

There's no clear, one-size-fits-all answer to this. The antidepressant effects of ketamine seem to be more short-lived (though not in everyone... for some there is a long-lasting effect). Psilocybin therapy seems to have a more long-lasting effect, and some people only need one to three treatments to never need it again, vs ketamine for which many people need many (perhaps indefinite) treatments. Then there are legal issues to consider. In the US, at least, ketamine can be used legally as off-label treatment for depression. As far as I know that's not the case for psilocybin yet, though you could get legal psilocybin therapy if you're part of a research study. It's also possible to get psychedelic therapy from an underground therapist.. or maybe you're in a country where it's legal. I'd suggest finding out as much as you can about both ketamine and psilocybin use in treating depression. There have been a lot of studies done on both, and a lot of good information about this.