3 ms·

I have tried all medicines that traditional psychiatry has to offer, and none of them have worked for me. Should I aim for Ketamine next, or Psilocybin?

by txtsd 5y ago

in3d 5y ago
I’m not a doctor but here is a decent summary: https://www.psychologytoday.com/us/blog/the-lucid-mind/202105/how-does-ketamine-work-differently-other-psychedelics https://www.psychologytoday.com/us/blog/the-lucid-mind/20210...
say_it_as_it_is 5y ago
Psilocybin needs to be taken with therapy treatment unless you're highly skilled with self-therapy. It opens pathways for change, but you still have to do the work to change your thought patterns. The work is started during the trip but follows during integration therapy.
hiram112 5y ago
MAOIs when all else fails.
- aidenn0 5y ago
  All the research I've read shows MAOIs as being extremely effective, but has so many interaction effects as to make it very likely to cause problems. Like no sauerkraut if you are on MAOIs.
pmoriarty 5y ago
There's no clear, one-size-fits-all answer to this. The antidepressant effects of ketamine seem to be more short-lived (though not in everyone... for some there is a long-lasting effect). Psilocybin therapy seems to have a more long-lasting effect, and some people only need one to three treatments to never need it again, vs ketamine for which many people need many (perhaps indefinite) treatments. Then there are legal issues to consider. In the US, at least, ketamine can be used legally as off-label treatment for depression. As far as I know that's not the case for psilocybin yet, though you could get legal psilocybin therapy if you're part of a research study. It's also possible to get psychedelic therapy from an underground therapist.. or maybe you're in a country where it's legal. I'd suggest finding out as much as you can about both ketamine and psilocybin use in treating depression. There have been a lot of studies done on both, and a lot of good information about this.

I have tried all medicines that traditional psychiatry has to offer, and none of them have worked for me. Should I aim for Ketamine next, or Psilocybin?

by txtsd 5y ago

I have tried all medicines that traditional psychiatry has to offer, and none of them have worked for me. Should I aim for Ketamine next, or Psilocybin?

in3d 5y ago

I’m not a doctor but here is a decent summary: https://www.psychologytoday.com/us/blog/the-lucid-mind/202105/how-does-ketamine-work-differently-other-psychedelics https://www.psychologytoday.com/us/blog/the-lucid-mind/20210...

say_it_as_it_is 5y ago

Psilocybin needs to be taken with therapy treatment unless you're highly skilled with self-therapy. It opens pathways for change, but you still have to do the work to change your thought patterns. The work is started during the trip but follows during integration therapy.

hiram112 5y ago

MAOIs when all else fails.

aidenn0 5y ago
All the research I've read shows MAOIs as being extremely effective, but has so many interaction effects as to make it very likely to cause problems. Like no sauerkraut if you are on MAOIs.

pmoriarty 5y ago

There's no clear, one-size-fits-all answer to this. The antidepressant effects of ketamine seem to be more short-lived (though not in everyone... for some there is a long-lasting effect). Psilocybin therapy seems to have a more long-lasting effect, and some people only need one to three treatments to never need it again, vs ketamine for which many people need many (perhaps indefinite) treatments. Then there are legal issues to consider. In the US, at least, ketamine can be used legally as off-label treatment for depression. As far as I know that's not the case for psilocybin yet, though you could get legal psilocybin therapy if you're part of a research study. It's also possible to get psychedelic therapy from an underground therapist.. or maybe you're in a country where it's legal. I'd suggest finding out as much as you can about both ketamine and psilocybin use in treating depression. There have been a lot of studies done on both, and a lot of good information about this.