3 ms·
Furin cleavage sites have evolved and are present in multiple coronaviruses: - HCoV-OC43 (infects humans) - HCoV-HKU1 (infects humans) - MHV-A59 - ChRCoV-HK
by lamontcg 5y ago
Furin cleavage sites have evolved and are present in multiple coronaviruses:
- HCoV-OC43 (infects humans)
- HCoV-HKU1 (infects humans)
- MHV-A59
- ChRCoV-HKU24
- BtCoV-ENT
- BtNeCoV-PML-PHE1
- BtCoV-HKU4
- BtCoV-HKU5
- MERS-CoV
- BtHpCoV-Zhejiang2013
- SARS-CoV-2
Phylogenetic analysis suggests that it has evolved independently at least 6 times that we know of.
https://www.sciencedirect.com/science/article/pii/S1873506120304165 https://www.sciencedirect.com/science/article/pii/S187350612...
After that article was published a team in Thailand found furin cleavage sites in sarbecoviruses closely related to SARS-CoV-2 called RacCS203 (91.5% similarity to SARS-CoV-2) and RmYN02 (93.3% similarity to SARS-CoV-2)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873279/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7873279/
Furin cleavage sites are common, nature understands how to utilize that trick very well, and continuously has re-discovered it.