In that particular case, I wouldn't say "the virus jumps directly to humans", because it is already a human-specific virus, just with a different spike protein.

In that particular case, I wouldn't say "the virus jumps directly to humans", because it is already a human-specific virus, just with a different spike protein. It may evade preexisting immunity (or maybe not, since the spike protein isn't the only point of attack), but that's about it. SARS-CoV-2 is decidedly nothing of the sort, the entire thing is unknown, while it has some resemblance to bat corona viruses. Viruses that pass through cell cultures are usually getting weaker, by the way. You'd have to "pass" them through actual human subjects to actively increase their pandemic potential. That would not only be unethical but also very difficult.