I should have been more clear about the monoclonals I was referring to, which are those targeting the virus itself (1). You may be thinking of the targeted imm

I should have been more clear about the monoclonals I was referring to, which are those targeting the virus itself (1). You may be thinking of the targeted immune modulators against inflammatory cytokines like TNF-alpha (2) and IL-6 (3). Some of those are antibodies, others are pieces of antibody fused to other proteins. Regardless, those types of treatments would not be affected directly by viral mutation, whereas the first type I described above have already been shown to be less effective with existing mutations (4). 1. https://en.m.wikipedia.org/wiki/Casirivimab/imdevimab https://en.m.wikipedia.org/wiki/Casirivimab/imdevimab 2. https://en.m.wikipedia.org/wiki/Casirivimab/imdevimab https://en.m.wikipedia.org/wiki/Casirivimab/imdevimab 3. https://www.covid19treatmentguidelines.nih.gov/immunomodulators/interleukin-6-inhibitors/ https://www.covid19treatmentguidelines.nih.gov/immunomodulat... 4. https://science.sciencemag.org/content/371/6531/850 https://science.sciencemag.org/content/371/6531/850