I actually just read your linked article a couple days ago... It's thesis is that the main side effects are easily detectable and reversible, and therefore grea

I actually just read your linked article a couple days ago... It's thesis is that the main side effects are easily detectable and reversible, and therefore greatly preferable to the aging-related problems that rapamycin keeps at bay. (ie, if you get a bacterial problem, lay off the rapamycin and maybe take a quick round of antibiotics. OTOH, If you get Alzheimer's, well...) The story with kidneys is a bit stranger. Heavy rapamycin use seems to trip up 'normal' levels in insulin-related measurements, but this may have a lot more to do with the body being in a different state than the usual measurements are calibrated for, and doesn't seem to be causing diabetes in practice. (to paraphrase, perhaps badly: in many ways, rapamycin acts like artificial calorie restriction, which does strange things to insulin handling anyways.)