4 ms·
Rapamycin can have bad side effects, especially on the kidneys and making the patient more susceptible to bacterial infections. Wise to look at dogs, if that is
by RachelF 5y ago
Rapamycin can have bad side effects, especially on the kidneys and making the patient more susceptible to bacterial infections. Wise to look at dogs, if that is the case.
https://pubmed.ncbi.nlm.nih.gov/31586989/ https://pubmed.ncbi.nlm.nih.gov/31586989/
- sdenton4 5y agoI actually just read your linked article a couple days ago... It's thesis is that the main side effects are easily detectable and reversible, and therefore greatly preferable to the aging-related problems that rapamycin keeps at bay. (ie, if you get a bacterial problem, lay off the rapamycin and maybe take a quick round of antibiotics. OTOH, If you get Alzheimer's, well...) The story with kidneys is a bit stranger. Heavy rapamycin use seems to trip up 'normal' levels in insulin-related measurements, but this may have a lot more to do with the body being in a different state than the usual measurements are calibrated for, and doesn't seem to be causing diabetes in practice. (to paraphrase, perhaps badly: in many ways, rapamycin acts like artificial calorie restriction, which does strange things to insulin handling anyways.)