3 ms·

Can I have an ELI5 of the TLDR?

• isoprophlex 5y ago
  The immune response works as follows: Strange new protein in your body -> immunity mRNA is the blueprint to a protein. You can get the mRNA into your body directly (super cool novel tech) or using a carrier virus that has the blueprint as DNA (eg. a modified chimpanzee cold in astrazeneca's covid vaccine). Here, the body first has to turn DNA into mRNA. The researchers show that the latter approach gives rise to errors in prodcing proteins, errors that can cause severe side effects.
  • ithkuil 5y ago
    which is an interesting example of where a "proven technology" can be less safe than the "new technology"
    • Izkata 5y ago
      The J&N and AstraZeneca method (adenovirus-vector) is only barely a "proven technology" - as far as I recall it's only been successfully used once before, in an Ebola vaccine that was created in 2015 and approved in 2020.
  • slimbods 5y ago
    Thanks. In that case, why doesn't the virus itself cause thrombatic side effects?