3 ms·
What I want to know is if the transcription of the spike protein of the SARS-CoV-2 also leads to dangerous C-terminal truncated spike proteins or that SARS-CoV-
by fsiefken 5y ago
What I want to know is if the transcription of the spike protein of the SARS-CoV-2 also leads to dangerous C-terminal truncated spike proteins or that SARS-CoV-2 transcription by definition doesn't lead to truncated spike proteins.
If so than catching SARS-CoV-2 is equally risky on this front.
From the abstract:
"..transcription of wildtype and codon-optimized Spike open reading frames enables alternative splice events that lead to C-terminal truncated, soluble Spike protein variants. These soluble Spike variants may initiate severe side effects when binding to ACE2-expressing endothelial cells in blood vessels"
- usrusr 5y agoI was asking myself the same question because some of the wording used is quite suggestive to a layman reader like me. But after some Wikipedia my answer is: no, the actual virus carries its blueprint in RNA form that doesn't go through that transcription step where the errors occur. In JVM lingo, it's as if one was .class and the other was a single-class .jar and somehow certain byte sequences were less reliable during unzip than others. And as a consequence, those byte sequence are avoided by programs routinely distributed as .jar but used quite generously by those distributed as .class. Now they took some snippets from a codebase that is deeply rooted in the ".class" tradition and inserted it into a vector from the ".jar" side and the unzip errors happened to be rare enough to not light up during QA.