The evidence for sirtuins is pretty good. Probably the first drug we find that extends life span in humans is going to be metformin or rapamycin. NR and NMN h

The evidence for sirtuins is pretty good. Probably the first drug we find that extends life span in humans is going to be metformin or rapamycin. NR and NMN have failed to extend lifespan in rats, so it probably doesn't work with humans. (I don't know anything about yamanaka factors.