4 ms·

>Also, it’s important to realize that initial viral load makes a significant difference in how sick people get. While that was an early hypothesis, I'm not sur

>Also, it’s important to realize that initial viral load makes a significant difference in how sick people get. While that was an early hypothesis, I'm not sure that has really been proven. A lot of the early data wasn't really "initial" viral load, but viral load when they presented in the hospital. That's not necessary an indication of initial viral load.

Retric 5y ago
In the end most viruses have similar interactions with the body. The immune system simply takes a while to physically respond which is why initial viral load is important. So, initial viral load is not COVID specific. Also viral load at first detection is a different yet important criteria for EBOLA, COVID, and other diseases. https://www.jci.org/articles/view/83162 https://www.jci.org/articles/view/83162
- rhino369 5y ago
  It doesn't follow that viral load at infection matters because the immune system takes a while to respond. You have a built in assumption that immune response is exactly the same whether there is 1 (arbitrary unit) virus vs. 50 (arbitrary unit) virus. I'm not sure that is true. I could imagine the body starting a heavy immune response at 100 virus--which would mean the difference between 1 and 50 might have little affect on outcome. Your paper is about viral load at diagnosis--not infection. Diagnosis happens after your immune system has been fighting a while.
  - Retric 5y ago
    That study was not supposed to refer to viral load at initial infection, you need to test viral load at exposure in a lab. The 1 vs 50 difference is known to be based in part on the innate immune system not just the adaptive immune system. Most of the time you don’t need to create specific antibodies etc. If only a single virus enters the body it’s likely for you to fight off the infection without noticing though with the downside of failing to develop long term immunity. https://en.m.wikipedia.org/wiki/Innate_immune_system https://en.m.wikipedia.org/wiki/Innate_immune_system The 50 vs 50,000 is a related though less proven idea. Extreme exposure can simply overwhelm the immune system and extreme cases directly result in septic shock, but the middle ground is harder to test.

Retric 5y ago

In the end most viruses have similar interactions with the body. The immune system simply takes a while to physically respond which is why initial viral load is important. So, initial viral load is not COVID specific. Also viral load at first detection is a different yet important criteria for EBOLA, COVID, and other diseases. https://www.jci.org/articles/view/83162 https://www.jci.org/articles/view/83162

rhino369 5y ago
It doesn't follow that viral load at infection matters because the immune system takes a while to respond. You have a built in assumption that immune response is exactly the same whether there is 1 (arbitrary unit) virus vs. 50 (arbitrary unit) virus. I'm not sure that is true. I could imagine the body starting a heavy immune response at 100 virus--which would mean the difference between 1 and 50 might have little affect on outcome. Your paper is about viral load at diagnosis--not infection. Diagnosis happens after your immune system has been fighting a while.
- Retric 5y ago
  That study was not supposed to refer to viral load at initial infection, you need to test viral load at exposure in a lab. The 1 vs 50 difference is known to be based in part on the innate immune system not just the adaptive immune system. Most of the time you don’t need to create specific antibodies etc. If only a single virus enters the body it’s likely for you to fight off the infection without noticing though with the downside of failing to develop long term immunity. https://en.m.wikipedia.org/wiki/Innate_immune_system https://en.m.wikipedia.org/wiki/Innate_immune_system The 50 vs 50,000 is a related though less proven idea. Extreme exposure can simply overwhelm the immune system and extreme cases directly result in septic shock, but the middle ground is harder to test.