4 ms·

By running your blood through a specific DNA methylation test - Illumina I believe. Not cheap stuff.

aantix 5y ago
Strangely, my son who is six, who has exhibited symptoms of schizophrenia and has been formally diagnosed with ODD (oppositional defiant disorder), responds incredibly well to a combination of Niacin/Magnesium. He becomes a different person when he has taken his vitamins for the day, a more caring person. It's been a profound transition, and one that we didn't expect. We had tried everything - improving sleep, improving diet, weekly behavioral therapy. Nothing has come remotely close to the impact that the Niacin/Magnesium combination. It's probably a 70% improvement in behavior. That dramatic. I stumbled across the works of Abram Hoffer. That this is probably an issue related to overmethylation within his system, and the B3 helps subside this issue. At least my very basic understanding. I know I am trivializing the domain - I don't mean to. Not sure how to confirm that overmethylation is the issue, hence why I was asking. Thanks for the insight. P.S. For those curious, this is the current protocol of vitamins we have been using to help him. https://aantix.medium.com/my-son-niacin-magnesium-and-the-treatment-of-oppositional-defiant-disorder-45998ada02d8 https://aantix.medium.com/my-son-niacin-magnesium-and-the-tr...
- zemvpferreira 5y ago
  That's amazing, it would definitely be a good investment to get as much data on his DNA as possible. A definite diagnosis will certainly have a huge impact on both your lives and your relationship. Thank you for sharing your specific protocol by the way, I was about to ask. I've tried Magtein before but nothing like the doses you describe, and never paired with Niacin
- goldenkey 5y ago
  Magnesium can cause stomach cramps and liquid shits. I hope you are monitoring this thorny effect..
  - aantix 5y ago
    Very aware. I get that periodically with glycinate. l-threonate is much lower dose of elemental magnesium, usually 144mg, but it's much more targeted.
    - goldenkey 5y ago
      Glad to hear it. L-threonate is actually what I had tried, and it caused the issues for me. Just constant "pudding poops" every time I took it. And I did the Rogan method of sandwiching the dose in the middle of a meal, so it would be around food in the stomach. Didn't help. I wanted to use it for its mental effects (depression and sleep issues), but unfortunately the stomach interference prevented me from ever using magnesium again. If you have any recommendations, I'd be happy to hear them. I hear such rave reviews about magnesium from so many people.
      - aantix 5y ago
        I've heard that this could be a (lack of) tolerance issue. Potentially micro-dose it and work your way up to see if the gradual introduction helps?
        goldenkey 5y ago
        Thanks for the advice. Makes sense. Perhaps I will try that.
- abcc8 5y ago
  While DNA methylation may be involved in the specific pathology you mention, it is by no means definitely involved. Both Magnesium and Niacin are cofactors utilized by many enzymes and their supplementation are likely having pleiotropic effects. *Edit: Added a mistakenly omitted word.
  - aantix 5y ago
    Do you have any actionable next steps we could take in terms of testing to isolate his condition? There could be a treatment that we've completely missed.
    - abcc8 5y ago
      Sure, I'd be happy to share, but this is just an opinion. Secure an appointment in a genetics clinic at a world-leading institution - think the sorts of hospitals that routinely see the rarest genetic diseases in the world, CHOP, CHLA, Rady in SD, Emory, Children's Boston, Lourie in Chicago (the children's hospital, not the cancer center), Nationwide in Columbus, Hopkins, etc. Ideally you'd be seeing someone who is continually identifying and publishing newly discovered genetic diseases. Compose a short, concise document detailing developmental milestones as well as symptoms. Include all interventions that you have found to work and not work. Include all prior test and imaging results. This document will be given to the geneticist and genetic counselors you meet with. You can also look into having the medical record transferred over from the primary care facility to the geneticist's office. Let them handle the rest. They may recommend testing, they may recommend consults with additional specialists, they may feel the issue is not genetic. It is important to keep in mind that one does not need to be far outside of the box to butt up against the limits of medical knowledge. It is possible that this strategy may not help. There are also research programs, such as the undiagnosed disease program at the NIH, that may also be potential avenues to pursue. It is also possible that the issue does not have an identifiable genetic cause, or if there is, the underlying pathology is currently not understood. Good luck.

Strangely, my son who is six, who has exhibited symptoms of schizophrenia and has been formally diagnosed with ODD (oppositional defiant disorder), responds incredibly well to a combination of Niacin/Magnesium. He becomes a different person when he has taken his vitamins for the day, a more caring person. It's been a profound transition, and one that we didn't expect. We had tried everything - improving sleep, improving diet, weekly behavioral therapy. Nothing has come remotely close to the impact that the Niacin/Magnesium combination. It's probably a 70% improvement in behavior. That dramatic. I stumbled across the works of Abram Hoffer. That this is probably an issue related to overmethylation within his system, and the B3 helps subside this issue. At least my very basic understanding. I know I am trivializing the domain - I don't mean to. Not sure how to confirm that overmethylation is the issue, hence why I was asking. Thanks for the insight. P.S. For those curious, this is the current protocol of vitamins we have been using to help him. https://aantix.medium.com/my-son-niacin-magnesium-and-the-treatment-of-oppositional-defiant-disorder-45998ada02d8 https://aantix.medium.com/my-son-niacin-magnesium-and-the-tr...

zemvpferreira 5y ago
That's amazing, it would definitely be a good investment to get as much data on his DNA as possible. A definite diagnosis will certainly have a huge impact on both your lives and your relationship. Thank you for sharing your specific protocol by the way, I was about to ask. I've tried Magtein before but nothing like the doses you describe, and never paired with Niacin
goldenkey 5y ago
Magnesium can cause stomach cramps and liquid shits. I hope you are monitoring this thorny effect..
- aantix 5y ago
  Very aware. I get that periodically with glycinate. l-threonate is much lower dose of elemental magnesium, usually 144mg, but it's much more targeted.
  - goldenkey 5y ago
    Glad to hear it. L-threonate is actually what I had tried, and it caused the issues for me. Just constant "pudding poops" every time I took it. And I did the Rogan method of sandwiching the dose in the middle of a meal, so it would be around food in the stomach. Didn't help. I wanted to use it for its mental effects (depression and sleep issues), but unfortunately the stomach interference prevented me from ever using magnesium again. If you have any recommendations, I'd be happy to hear them. I hear such rave reviews about magnesium from so many people.
    - aantix 5y ago
      I've heard that this could be a (lack of) tolerance issue. Potentially micro-dose it and work your way up to see if the gradual introduction helps?
      - goldenkey 5y ago
        Thanks for the advice. Makes sense. Perhaps I will try that.
abcc8 5y ago
While DNA methylation may be involved in the specific pathology you mention, it is by no means definitely involved. Both Magnesium and Niacin are cofactors utilized by many enzymes and their supplementation are likely having pleiotropic effects. *Edit: Added a mistakenly omitted word.
- aantix 5y ago
  Do you have any actionable next steps we could take in terms of testing to isolate his condition? There could be a treatment that we've completely missed.
  - abcc8 5y ago
    Sure, I'd be happy to share, but this is just an opinion. Secure an appointment in a genetics clinic at a world-leading institution - think the sorts of hospitals that routinely see the rarest genetic diseases in the world, CHOP, CHLA, Rady in SD, Emory, Children's Boston, Lourie in Chicago (the children's hospital, not the cancer center), Nationwide in Columbus, Hopkins, etc. Ideally you'd be seeing someone who is continually identifying and publishing newly discovered genetic diseases. Compose a short, concise document detailing developmental milestones as well as symptoms. Include all interventions that you have found to work and not work. Include all prior test and imaging results. This document will be given to the geneticist and genetic counselors you meet with. You can also look into having the medical record transferred over from the primary care facility to the geneticist's office. Let them handle the rest. They may recommend testing, they may recommend consults with additional specialists, they may feel the issue is not genetic. It is important to keep in mind that one does not need to be far outside of the box to butt up against the limits of medical knowledge. It is possible that this strategy may not help. There are also research programs, such as the undiagnosed disease program at the NIH, that may also be potential avenues to pursue. It is also possible that the issue does not have an identifiable genetic cause, or if there is, the underlying pathology is currently not understood. Good luck.