4 ms·

> with its self-rewrite immune escape functionality. Interesting! Could you elaborate on this or provide a link? > but also because the spike protein was alre

> with its self-rewrite immune escape functionality. Interesting! Could you elaborate on this or provide a link? > but also because the spike protein was already "solved" ahead of the pandemic. I would also be interested in further information on that? Thanks

H8crilA 5y ago
For the first you can just Google for "hiv rapid mutation", example: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414815/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414815/. The OP article contains a lot of details too. For the second see something like "covid spike sequence modification", for example this seems like an accessible article: https://cen.acs.org/pharmaceuticals/vaccines/tiny-tweak-behind-COVID-19/98/i38 https://cen.acs.org/pharmaceuticals/vaccines/tiny-tweak-behi... It was all thanks to the research on previous coronaviruses, MERS specifically. The Pfizer/Moderna vaccines have just copied it (of course that simple modification is not all it took, but that was definitely required for success).