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Do the vaccinations or which vaccinations produce similar results?

by 1cvmask 5y ago

kurthr 5y ago
Yes, it appears they do... at least for the tested mRNA vaccines, which dominated early availability.
- beerandt 5y ago
  I still haven't seen anything about any infection-caused natural immunity involving anything other than the spike protein chosen for the mRNA vaccines. Surely some people's immune system must be making antibodies targeting other features of the virus? I know that might not make a practical difference at this point in terms of immunity, but it seems relevant to studies like these in terms of long-term, breadth vs depth immunity strategies that the body implements.
  - CorrectHorseBat 5y ago
    Here is one, I'm sure there's more: https://www.biorxiv.org/content/10.1101/2021.04.15.440089v4 https://www.biorxiv.org/content/10.1101/2021.04.15.440089v4 I don't remember where I read it or why exactly they did it, but I read this is already used to be able to test whether your antibodies come from natural infection or vaccination.
  - kurthr 5y ago
    Those (spike protein) are the tests that are readily available, although they do have others that target other relatively stable portions of the virus. In fact the way that the "English'-B.1.1.7 and "South African" B.1.351 were originally discovered (before sequencing) was that they didn't replicate one of the PCR primers, but they are still targeting the functional element, which is required for replication/infection. There are lots of things your body might respond to and even effectively fight off a COVID infection, it's just that not all of them are particularly stable. If you go to Nextstrain you can actually see which protein the different mutations are in (S is for spike). They're all over the place, but many change so much that you could have multiple strains within a single infection. RNA viruses are not very stable. Only the required functionality of the spike provides a relatively stable attack point. spike (S), envelope (E), membrane (M), nucleocapsid (N) https://nextstrain.org/ncov/global https://nextstrain.org/ncov/global

Do the vaccinations or which vaccinations produce similar results?

kurthr 5y ago

Yes, it appears they do... at least for the tested mRNA vaccines, which dominated early availability.

beerandt 5y ago
I still haven't seen anything about any infection-caused natural immunity involving anything other than the spike protein chosen for the mRNA vaccines. Surely some people's immune system must be making antibodies targeting other features of the virus? I know that might not make a practical difference at this point in terms of immunity, but it seems relevant to studies like these in terms of long-term, breadth vs depth immunity strategies that the body implements.
- CorrectHorseBat 5y ago
  Here is one, I'm sure there's more: https://www.biorxiv.org/content/10.1101/2021.04.15.440089v4 https://www.biorxiv.org/content/10.1101/2021.04.15.440089v4 I don't remember where I read it or why exactly they did it, but I read this is already used to be able to test whether your antibodies come from natural infection or vaccination.
- kurthr 5y ago
  Those (spike protein) are the tests that are readily available, although they do have others that target other relatively stable portions of the virus. In fact the way that the "English'-B.1.1.7 and "South African" B.1.351 were originally discovered (before sequencing) was that they didn't replicate one of the PCR primers, but they are still targeting the functional element, which is required for replication/infection. There are lots of things your body might respond to and even effectively fight off a COVID infection, it's just that not all of them are particularly stable. If you go to Nextstrain you can actually see which protein the different mutations are in (S is for spike). They're all over the place, but many change so much that you could have multiple strains within a single infection. RNA viruses are not very stable. Only the required functionality of the spike provides a relatively stable attack point. spike (S), envelope (E), membrane (M), nucleocapsid (N) https://nextstrain.org/ncov/global https://nextstrain.org/ncov/global