4 ms·
HCoV-NL63 enters cells via ACE2 and only causes the common cold.
by lamontcg 5y ago
HCoV-NL63 enters cells via ACE2 and only causes the common cold.
- deleted 5y ago[deleted]
- thowaway959125 5y agoVery interesting. This is certainly a scientifically valid response. > Here we show that SARS-CoV, but not HCoV-NL63, utilizes the enzymatic activity of the cysteine protease cathepsin L to infect ACE2-expressing cells. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142358/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142358/
- lamontcg 5y agoThe vastly more likely significant differences are: 1. We don't (yet) inherit antibodies to SARS-CoV-2 from our mothers. 2. SARS-CoV-2 has not been forced to make evolutionary sacrifices to evolve to escape immunity. The virus has the freedom to become optimally bad and our immune systems were optimally naive. Over time the warfare between our immune system and the virus should cause SARS-CoV-2 to look a lot more like HCoV-NL63. That's a sufficient explanation of the differences in disease severity without having to troll through medical articles.