We would have seen evidence of ADE by now. From convalescent plasma to naturally re-exposed and reinfected to the individuals vaccinated almost a year ago now.

We would have seen evidence of ADE by now. From convalescent plasma to naturally re-exposed and reinfected to the individuals vaccinated almost a year ago now. And the vaccines target spike because there were concerns about ADE with vaccines against the SARS-CoV-1 nucleocapsid protein, but not spike. Pfizer stimulates both CD4+ and CD8+ T-cells responses: https://www.fiercebiotech.com/biotech/pfizer-reports-strong-t-cell-response-to-covid-19-vaccine https://www.fiercebiotech.com/biotech/pfizer-reports-strong-... https://www.medrxiv.org/content/10.1101/2020.07.17.20140533v1.full.pdf https://www.medrxiv.org/content/10.1101/2020.07.17.20140533v... And the stuff in there about IL-4 and IL-5 and "the absence of a potentially deleterious TH2 immune response" is all about "no signs of ADE".