It might be easier to think about these numbers if you know that the average mass of an amino acid is 110 daltons. So 180 kda is around 1,600 residues. From th

It might be easier to think about these numbers if you know that the average mass of an amino acid is 110 daltons. So 180 kda is around 1,600 residues. From this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055910/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3055910/ > Peptides from 10 to 30 kDa typically fold into a single domain. Peptides larger than 50 kDa typically form two or more domains that are independently folded. So most larger proteins are formed from complexes of smaller ones. That said, there are some amazing examples, such as the proteasome, or the vault. See https://pubs.rsc.org/en/content/articlehtml/2015/cs/c5cs00157a https://pubs.rsc.org/en/content/articlehtml/2015/cs/c5cs0015... for more detail