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My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people wh

My father tested negative for spike specific antibodies 2 weeks after the 2nd Pfizer vaccine (he's not the only one), and as I didn't find any data on people who test negative (and I know that the vaccine has 94% efficiency preventing COVID), he's still mostly not leaving his apartment. He'll have a test against the viruses themselves next week, but he'll need to wait 2 weeks for the result for that test.

tdeck 5y ago
How did he happen to get that antibody test?
- xiphias2 5y ago
  A nurse came to his apartment to take the test (I payed for it)
  - tdeck 5y ago
    That's cool! I had no idea those were available to the general public.
- tgsovlerkhgsel 5y ago
  (not the person you asked) I opted to have one done (out of pocket) when I was doing an unrelated blood test, since I had gotten sick around the time COVID started to be an issue in my area. It's just a matter of checking an additional checkbox on the lab request (if you have the blood taken at a lab) or asking your doctor "hey, can you please also check box X" if the sample is taken at a doctor. Would have definitely stuck to the bare minimum of government-mandated precautions if it had been positive.
rgbbtc4life 5y ago
If the vaccine is truly 95% effective in preventing infection, how did 9 fully vaccinated Yankees players all contract the virus?
- verdverm 5y ago
  1. It was a single player, the rest were other staff 2. Vaccines don't prevent infection, they reduce severity by training the body's immune system. Natural exposure works the same way. This it is not surprising that 8/9 Yankees which tested positive were asymptomatic
  - atty 5y ago
    This is incorrect - from population studies, we now know that both the mRNA vaccines reduce infection rates and reduce severity of symptoms for those who do get infected. In fact, they both show about 90% efficacy at preventing infection at all. That number is probably trending down a bit with all the new strains, but it is still very high.
    - verdverm 5y ago
      I suppose that depends on how infection is defined. Nothing prevents the virus from entering the body and triggering a positive test result, especially when the tests are run with longer cycle times
    - _coveredInBees 5y ago
      The Yankee players all had J&J vaccines, so not the mRNA variety.
      - verdverm 5y ago
        https://www.cnn.com/2021/05/20/health/yankees-covid-19-breakthrough-infections/index.html https://www.cnn.com/2021/05/20/health/yankees-covid-19-break... The Yankees are reported to be using the J&J vaccine, which is a viral vector product.
  - standardUser 5y ago
    I don't know where this misinformation came from, but it is absolutely false. COVID vaccines have been shown to prevent infection... https://www.cdc.gov/media/releases/2021/p0329-COVID-19-Vaccines.html#:~:text=LinkedIn-,CDC%20Real%2DWorld%20Study%20Confirms%20Protective,of%20mRNA%20COVID%2D19%20Vaccines&text=A%20new%20CDC%20study%20provides,responders%2C%20and%20other%20essential%20workers https://www.cdc.gov/media/releases/2021/p0329-COVID-19-Vacci....
yosito 5y ago
I wonder if an expert could chime in on this. If someone tests negative for antibodies a few weeks after a vaccine, should that person get vaccinated again? Maybe with a different vaccine?
azinman2 5y ago
That doesn’t mean he doesn’t have protection. The antibody tests only look For one thing, but the body has many mechanisms of protection from the vaccine. That is one of the reasons why they’re not suggested to be used for the general population.
- xiphias2 5y ago
  I know that it doesn't mean that he isn't protected, but I didn't find data on the protection against severe covid disease with the conditional probability of spike specific antibody test being negative after being properly vaccinated. Instead of just guidance I would like to see data. Anyways that's why there are specific, slower test that can test his protection against specific virus mutations.
inter_netuser 5y ago
Has he been tested for immune deficiencies? What is his age? Have a contact that's an NIH immunologist, want to get his opinion. tia

tdeck 5y ago

How did he happen to get that antibody test?

xiphias2 5y ago
A nurse came to his apartment to take the test (I payed for it)
- tdeck 5y ago
  That's cool! I had no idea those were available to the general public.
tgsovlerkhgsel 5y ago
(not the person you asked) I opted to have one done (out of pocket) when I was doing an unrelated blood test, since I had gotten sick around the time COVID started to be an issue in my area. It's just a matter of checking an additional checkbox on the lab request (if you have the blood taken at a lab) or asking your doctor "hey, can you please also check box X" if the sample is taken at a doctor. Would have definitely stuck to the bare minimum of government-mandated precautions if it had been positive.

rgbbtc4life 5y ago

If the vaccine is truly 95% effective in preventing infection, how did 9 fully vaccinated Yankees players all contract the virus?

verdverm 5y ago
1. It was a single player, the rest were other staff 2. Vaccines don't prevent infection, they reduce severity by training the body's immune system. Natural exposure works the same way. This it is not surprising that 8/9 Yankees which tested positive were asymptomatic
- atty 5y ago
  This is incorrect - from population studies, we now know that both the mRNA vaccines reduce infection rates and reduce severity of symptoms for those who do get infected. In fact, they both show about 90% efficacy at preventing infection at all. That number is probably trending down a bit with all the new strains, but it is still very high.
  - verdverm 5y ago
    I suppose that depends on how infection is defined. Nothing prevents the virus from entering the body and triggering a positive test result, especially when the tests are run with longer cycle times
  - _coveredInBees 5y ago
    The Yankee players all had J&J vaccines, so not the mRNA variety.
    - verdverm 5y ago
      https://www.cnn.com/2021/05/20/health/yankees-covid-19-breakthrough-infections/index.html https://www.cnn.com/2021/05/20/health/yankees-covid-19-break... The Yankees are reported to be using the J&J vaccine, which is a viral vector product.
- standardUser 5y ago
  I don't know where this misinformation came from, but it is absolutely false. COVID vaccines have been shown to prevent infection... https://www.cdc.gov/media/releases/2021/p0329-COVID-19-Vaccines.html#:~:text=LinkedIn-,CDC%20Real%2DWorld%20Study%20Confirms%20Protective,of%20mRNA%20COVID%2D19%20Vaccines&text=A%20new%20CDC%20study%20provides,responders%2C%20and%20other%20essential%20workers https://www.cdc.gov/media/releases/2021/p0329-COVID-19-Vacci....

yosito 5y ago

I wonder if an expert could chime in on this. If someone tests negative for antibodies a few weeks after a vaccine, should that person get vaccinated again? Maybe with a different vaccine?

azinman2 5y ago

That doesn’t mean he doesn’t have protection. The antibody tests only look For one thing, but the body has many mechanisms of protection from the vaccine. That is one of the reasons why they’re not suggested to be used for the general population.

xiphias2 5y ago
I know that it doesn't mean that he isn't protected, but I didn't find data on the protection against severe covid disease with the conditional probability of spike specific antibody test being negative after being properly vaccinated. Instead of just guidance I would like to see data. Anyways that's why there are specific, slower test that can test his protection against specific virus mutations.

inter_netuser 5y ago

Has he been tested for immune deficiencies? What is his age? Have a contact that's an NIH immunologist, want to get his opinion. tia