3 ms·
I'm not an expert so maybe someone can give a better response, but I've understood CRISPR as something that doesn't necessarily edit all the targeted cells, jus
by elihu 5y ago
I'm not an expert so maybe someone can give a better response, but I've understood CRISPR as something that doesn't necessarily edit all the targeted cells, just some proportion of them. So, maybe if one doesn't want to eliminate the production of a compound entirely, one sets the dose low enough to to only edit the genes of, say, half the targeted cells.
If I'm interpreting the article correctly, though, it sounds like in their trials they think they may have edited nearly all the targeted cells.
- f6v 5y ago> one sets the dose low enough to to only edit the genes of, say, half the targeted cells Using the single-cell sequencing we’ve learned that disease is sometimes driven by a very small sub-population of cells(e.g. cancer treatment resistance). There’s no way of knowing how the organism will respond to a perturbation even in 1% of the cells.