5 ms·

Could you post links to this evidence? I can only find sources saying that the Furin cleavage site doesn’t rule out engineering, or sources saying the Furin cl

Could you post links to this evidence? I can only find sources saying that the Furin cleavage site doesn’t rule out engineering, or sources saying the Furin cleave site could be naturally occurring. Sounds like we don’t know yet.

hilbertseries 5y ago
Here’s some evidence that it is naturally occurring from a virologist. https://twitter.com/wanderer_jasnah/status/1394247714024660994 https://twitter.com/wanderer_jasnah/status/13942477140246609...
- 1024core 5y ago
  I read it in Nicholas Wade's article: https://nicholaswade.medium.com/origin-of-covid-following-the-clues-6f03564c038 https://nicholaswade.medium.com/origin-of-covid-following-th... (long read). Some more reading: https://www.news-medical.net/news/20210217/The-origin-of-SARS-CoV-2-furin-cleavage-site-remains-a-mystery.aspx https://www.news-medical.net/news/20210217/The-origin-of-SAR... All these lines of evidence and reasoning show that the acquisition of the polybasic furin cleavage site by SARS-CoV-2 is a “missing link” in our understanding of its evolutionary history, that can only be addressed through the discovery of new viruses.”
salawat 5y ago
As I recall this article by Nicholas Wade goes into why the Furin cleavage site is a strong signal of potential active engineering in the GoF vein. https://nicholaswade.medium.com/origin-of-covid-following-the-clues-6f03564c038 https://nicholaswade.medium.com/origin-of-covid-following-th... As addition of a Furin cleavage site is an old hat acknowledged technique for increasing human infectivity of a virus. The issue with a zoonotic origin though, is that the odds of a mutation is incredibly small, and a recombination at that site would require the sequence to exist in another coronavirus, which has not been discovered to date. It is also known WIV researchers had recieved instruction from another virologist on "no-see-um" editing techniques that would not leave traces of the mechanism used to splice in an edit. So not proof, but the network of coincidence is as hard to ignore as a spinal tap amp duct taped to your head, cranked to 11, playing the 1812 Overture.
- shlant 5y ago
  for anyone interested in more information about this commonly parroted "smoking gun" (Furin cleavage site): https://twitter.com/K_G_Andersen/status/1391507230848032772 https://twitter.com/K_G_Andersen/status/1391507230848032772

hilbertseries 5y ago

Here’s some evidence that it is naturally occurring from a virologist. https://twitter.com/wanderer_jasnah/status/1394247714024660994 https://twitter.com/wanderer_jasnah/status/13942477140246609...

1024core 5y ago
I read it in Nicholas Wade's article: https://nicholaswade.medium.com/origin-of-covid-following-the-clues-6f03564c038 https://nicholaswade.medium.com/origin-of-covid-following-th... (long read). Some more reading: https://www.news-medical.net/news/20210217/The-origin-of-SARS-CoV-2-furin-cleavage-site-remains-a-mystery.aspx https://www.news-medical.net/news/20210217/The-origin-of-SAR... All these lines of evidence and reasoning show that the acquisition of the polybasic furin cleavage site by SARS-CoV-2 is a “missing link” in our understanding of its evolutionary history, that can only be addressed through the discovery of new viruses.”

salawat 5y ago

As I recall this article by Nicholas Wade goes into why the Furin cleavage site is a strong signal of potential active engineering in the GoF vein. https://nicholaswade.medium.com/origin-of-covid-following-the-clues-6f03564c038 https://nicholaswade.medium.com/origin-of-covid-following-th... As addition of a Furin cleavage site is an old hat acknowledged technique for increasing human infectivity of a virus. The issue with a zoonotic origin though, is that the odds of a mutation is incredibly small, and a recombination at that site would require the sequence to exist in another coronavirus, which has not been discovered to date. It is also known WIV researchers had recieved instruction from another virologist on "no-see-um" editing techniques that would not leave traces of the mechanism used to splice in an edit. So not proof, but the network of coincidence is as hard to ignore as a spinal tap amp duct taped to your head, cranked to 11, playing the 1812 Overture.

shlant 5y ago
for anyone interested in more information about this commonly parroted "smoking gun" (Furin cleavage site): https://twitter.com/K_G_Andersen/status/1391507230848032772 https://twitter.com/K_G_Andersen/status/1391507230848032772