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This is not actually a mechanism in our cells. The virus RNA folds in a particular way that interferes with how the ribosome usually works. Imagine it like a ma
by fabian2k 5y ago
This is not actually a mechanism in our cells. The virus RNA folds in a particular way that interferes with how the ribosome usually works. Imagine it like a machine that takes in a an RNA strand, and you make a knot in the strand. The machine can untangle the knot with some force, but slips while it is doing this and the alignment of the strand shifts and the machine continues on a different position on the strand than before. What they propose is to target the knot with a drug, not our cells.
- TacticalMalice 5y agoTranslational frameshifting is a feature of the human PEG10 mRNA, https://www.genecards.org/cgi-bin/carddisp.pl?gene=PEG10 https://www.genecards.org/cgi-bin/carddisp.pl?gene=PEG10 http://recode.ucc.ie/search?q=homo+sapiens http://recode.ucc.ie/search?q=homo+sapiens lists a number of other recode events.