My experience with optimizing Python code after ~10y is that after a certain point it's just not worth it and you'd be better off rewriting in a more performant

My experience with optimizing Python code after ~10y is that after a certain point it's just not worth it and you'd be better off rewriting in a more performant runtime once you hit that. That includes experiments I did with pypy, Cython and Numba for various projects.