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The article seems to be talking about two potentially unrelated effects - up-regulation of gluconeogenesis in the liver and BCAT1. The gluconeogenesis makes se
by autojoechen 5y ago
The article seems to be talking about two potentially unrelated effects - up-regulation of gluconeogenesis in the liver and BCAT1. The gluconeogenesis makes sense in the presence of glucose-hungry cells, the body would start making its own to stabilize blood sugar. I wonder what the signal mechanism is for the BCAT1 up-regulation?
- agumonkey 5y agotalking about glucose and tumors, anybody knows some good reads about benefits of ketogenic or similarly low sugar diets in regards to cancer ?
- bawolff 5y agoIf you pick your reading based on the answer you want to hear, you're only going to ever get confirmation bias.
- agumonkey 5y agoI'm not thank you
- chadcmulligan 5y agoIntermittent fasting seems to have a net positive effect, and the Mediterranean diet seems anti cancer - you live longer. A search will turn up multiple scholarly references.
- hellbannedguy 5y agoI sometimes feel like only eating when very hungry might be the only reason I'm still around. I was no rock star, but had many of the same habits. I have a gut feeling that eating less food might be better than any other healthy living tips. (To those fasting. I have know two people, one a Chiropractor, who went on strict fasts. Both ended up in the hospital over their appendix bursting. I will always remember what my grandfather told me. Everything in moderation.)
- agumonkey 5y agoYes, extremes aren't good. But variety and light diet seems a fair bet.
- CryptoPunk 5y agoCaloric restriction is one of the most reliable ways to increase the possibility of extending life. Fasting is also known to be beneficial. IIRC, you don't need very long fasts to get the full benefits.
- Fezzik 5y agoNot related to cancer, but the general consensus in the medical community seems to be that keto is NOT a healthy diet. Though it can help with weight loss it contributes to poor heart health and just generally mucks up your cardiovascular system (that’s my medical term, not a doctor’s). I gained a few pounds during Covid and my GPs first, unprompted, advice was to avoid keto at all costs. Additional anecdote: my uncle recently lost a good amount of weight on a keto diet (5’8”, was 220 now about 168) and he promptly had a heart-attack. Doctors said he had “diabetic arteries” and that the keto diet was at least a contributing factor.
- adrianN 5y agoI think getting any clear results in nutrition is essentially impossible because you can't conduct the studies necessary to get rid of all the confounding factors. Consequently it's probably a bad idea to follow an extreme diet. Of course that doesn't mean that keto (or other dietary interventions) can't be beneficial for certain illnesses like cancer. I'd be interested to hear about studies.
- otabdeveloper4 5y agoOur modern standard diet is very extreme by default. I'd guess practically any other diet would be better.
- adrianN 5y agoI guess it depends on your culture what the "standard" diet is. I don't think my diet is particularly extreme.
- otabdeveloper4 5y agoThe one that has white flour/rice and sugar as the main staples. You know what I mean; it's cross-cultural now, like tobacco smoking.
- 5y ago
- jdale27 5y agoLook into Thomas Seyfried's work, e.g. https://www.frontiersin.org/articles/10.3389/fnut.2020.00021/full https://www.frontiersin.org/articles/10.3389/fnut.2020.00021... and his book "Cancer as a Metabolic Disease".
- otabdeveloper4 5y agoCool, thanks. What about benign tumors, did anybody research those?
- agumonkey 5y agoHe's very visible on youtube, which is as good as bad, but I like his thinking approach.