I'd also be curious to hear about an expert weigh in on "original antigenic sin" in this context. (My lay understanding: your immune system gets partially locke

I'd also be curious to hear about an expert weigh in on "original antigenic sin" in this context. (My lay understanding: your immune system gets partially locked onto its first response to an antigen, and may fail to respond as well as it could to future variants). If you power up the response to massive levels, does it also augment the downsides of that "original antigenic sin"?