That’s why there’s a monument to a mouse [0]. > Is there, realistically, anything that would change this? In all confidence, nothing is going to replace anima

That’s why there’s a monument to a mouse [0]. > Is there, realistically, anything that would change this? In all confidence, nothing is going to replace animal models in science for decades to come(at least when we talk about biology). Yes, you can study development and disease in cell culture or organoids to some extent. But those don’t match the dynamics of a fully-functioning organism. Even though findings from mouse experiments often don’t translate well to humans, it’s our best bet. Computational biology can reduce the amount of experiments you need to do. For example, you can try to predict drug toxicity or identify key regulators of a certain cell type. But there’re always false positives(gene-regulatory networks are like 90% FP) and you always need to go back to the lab. If anything, I hope for more in-vivo experiments with the developments in CRISPR. [0] https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mouse https://en.wikipedia.org/wiki/Monument_to_the_laboratory_mou...