The entire VM is different: - you can replace builtins in python. - you have __dunder__ methods and multiple inheritance. - JS has an ever running event loop a

The entire VM is different: - you can replace builtins in python. - you have __dunder__ methods and multiple inheritance. - JS has an ever running event loop and is async by default. - python is more strickly typed. It's not impossible (see brython), but it's not easy either.